脑钠肽或n端前脑钠肽对机械通气患者脱机结局的预测价值:来自SROC的证据。

IF 2.1 4区 医学 Q3 PERIPHERAL VASCULAR DISEASE
Jian Liu, Chuan-Jiang Wang, Jun-Huai Ran, Shi-Hui Lin, Dan Deng, Yu Ma, Fang Xu
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引用次数: 6

摘要

目的:机械通气是危重患者的重要治疗手段。医生通常会进行自发呼吸试验(SBT)来确定患者是否可以脱离机械通气,但几乎17%通过SBT的患者仍然需要呼吸支持。心功能障碍是导致脱机失败的重要原因。使用脑利钠肽或n端前bnp是评估心功能的一种简单方法。我们对脑利钠肽或n端前bnp作为机械通气脱机预测因子的研究进行了系统回顾。数据来源:PubMed(1950年至2020年12月)、Cochrane和Embase(1974年至2020年12月),以及一些中文数据库(中国生物医学(CBM)、中国科技期刊数据库(CSTJ)和万方数据和中国知网)。研究选择:我们系统地检索了研究脑钠肽或n端脑钠肽前体对机械通气患者脱机预后预测价值的观察性研究。数据提取:两个独立的审稿人提取数据。分歧是通过协商解决的。资料综合:我们纳入了18篇文献,1416例患者,提取了6个指标试验,每个指标试验的敏感性和特异性汇总。对于预测断奶成功率的BNP变化率,合并敏感性为89%(83%-94%),合并特异性为82%(72%-89%),合并AUC最高为0.9511。结论:脑利钠肽变化率是机械通气断奶结局的可靠预测指标。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

The predictive value of brain natriuretic peptide or N-terminal pro-brain natriuretic peptide for weaning outcome in mechanical ventilation patients: Evidence from SROC.

The predictive value of brain natriuretic peptide or N-terminal pro-brain natriuretic peptide for weaning outcome in mechanical ventilation patients: Evidence from SROC.

The predictive value of brain natriuretic peptide or N-terminal pro-brain natriuretic peptide for weaning outcome in mechanical ventilation patients: Evidence from SROC.

The predictive value of brain natriuretic peptide or N-terminal pro-brain natriuretic peptide for weaning outcome in mechanical ventilation patients: Evidence from SROC.

Objective: Mechanical ventilation is an important treatment for critically ill patients. Physicians generally perform a spontaneous breathing trial (SBT) to determine whether the patients can be weaned from mechanical ventilation, but almost 17% of the patients who pass the SBT still require respiratory support. Cardiac dysfunction is an important cause of weaning failure. The use of brain natriuretic peptide or N-terminal pro-BNP is a simple method to assess cardiac function. We performed a systematic review of investigations of brain natriuretic peptide or N-terminal pro-BNP as predictors of weaning from mechanical ventilation.

Data sources: PubMed (1950 to December 2020), Cochrane, and Embase (1974 to December 2020), and some Chinese databases for additional articles (China Biology Medicine (CBM), China Science and Technology Journal Database (CSTJ), and Wanfang Data and China National Knowledge Infrastructure (CNKI)).

Study selection: We systematically searched observation studies investigating the predictive value of brain natriuretic peptide or N-terminal pro-brain natriuretic peptide in weaning outcome of patients with mechanical ventilation.

Data extraction: Two independent reviewers extracted data. The differences are resolved through consultation.

Data synthesis: We included 18 articles with 1416 patients and extracted six index tests with pooled sensitivity and specificity for each index test. For the BNP change rate predicting weaning success, the pooled sensitivity was 89% (83%-94%) and the pooled specificity was 82% (72%-89%) with the highest pooled AUC of 0.9511.

Conclusions: The brain natriuretic peptide change rate is a reliable predictor of weaning outcome from mechanical ventilation.

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来源期刊
CiteScore
6.20
自引率
0.00%
发文量
16
审稿时长
6-12 weeks
期刊介绍: JRAAS is a peer-reviewed, open access journal, serving as a resource for biomedical professionals, primarily with an active interest in the renin-angiotensin-aldosterone system in humans and other mammals. It publishes original research and reviews on the normal and abnormal function of this system and its pharmacology and therapeutics, mostly in a cardiovascular context but including research in all areas where this system is present, including the brain, lungs and gastro-intestinal tract.
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