靶向肿瘤微环境中的髓源性抑制细胞以提高肿瘤免疫治疗的疗效。

IF 2 4区医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

Discovery medicine Pub Date : 2020-11-01

Shuping Huo, Liang Liu, Qiaomin Li, Jing Wang

{"title":"靶向肿瘤微环境中的髓源性抑制细胞以提高肿瘤免疫治疗的疗效。","authors":"Shuping Huo, Liang Liu, Qiaomin Li, Jing Wang","doi":"","DOIUrl":null,"url":null,"abstract":"Myeloid-derived suppressor cells (MDSCs) are immature suppressive cells partly influencing the efficacy of cancer immunotherapies. The crosstalk between MDSCs and immune cells mediates a potently immunosuppressive network within the tumor microenvironment to attenuate the anti-tumor response. Targeting MDSCs could be a potential therapeutic approach to overcome the limitation of immunotherapies. In this article, we will review available information on how MDSCs exert their immunosuppressive function and summarize the therapeutic strategies targeting them to enhance the efficacy of cancer immunotherapies.","PeriodicalId":11379,"journal":{"name":"Discovery medicine","volume":"30 161","pages":"119-128"},"PeriodicalIF":2.0000,"publicationDate":"2020-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Targeting myeloid-derived suppressive cells in the tumor microenvironment to enhance the efficacy of cancer immunotherapy.\",\"authors\":\"Shuping Huo, Liang Liu, Qiaomin Li, Jing Wang\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Myeloid-derived suppressor cells (MDSCs) are immature suppressive cells partly influencing the efficacy of cancer immunotherapies. The crosstalk between MDSCs and immune cells mediates a potently immunosuppressive network within the tumor microenvironment to attenuate the anti-tumor response. Targeting MDSCs could be a potential therapeutic approach to overcome the limitation of immunotherapies. In this article, we will review available information on how MDSCs exert their immunosuppressive function and summarize the therapeutic strategies targeting them to enhance the efficacy of cancer immunotherapies.\",\"PeriodicalId\":11379,\"journal\":{\"name\":\"Discovery medicine\",\"volume\":\"30 161\",\"pages\":\"119-128\"},\"PeriodicalIF\":2.0000,\"publicationDate\":\"2020-11-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Discovery medicine\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"MEDICINE, RESEARCH & EXPERIMENTAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Discovery medicine","FirstCategoryId":"3","ListUrlMain":"","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MEDICINE, RESEARCH & EXPERIMENTAL","Score":null,"Total":0}

引用次数: 0

摘要

髓源性抑制细胞(MDSCs)是一种不成熟的抑制细胞，在一定程度上影响癌症免疫治疗的疗效。MDSCs和免疫细胞之间的串扰在肿瘤微环境中介导了一个有效的免疫抑制网络，以减弱抗肿瘤反应。靶向MDSCs可能是一种克服免疫疗法局限性的潜在治疗方法。在本文中，我们将回顾MDSCs如何发挥其免疫抑制功能的现有信息，并总结针对它们的治疗策略，以提高癌症免疫治疗的疗效。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

本刊更多论文

Targeting myeloid-derived suppressive cells in the tumor microenvironment to enhance the efficacy of cancer immunotherapy.

Myeloid-derived suppressor cells (MDSCs) are immature suppressive cells partly influencing the efficacy of cancer immunotherapies. The crosstalk between MDSCs and immune cells mediates a potently immunosuppressive network within the tumor microenvironment to attenuate the anti-tumor response. Targeting MDSCs could be a potential therapeutic approach to overcome the limitation of immunotherapies. In this article, we will review available information on how MDSCs exert their immunosuppressive function and summarize the therapeutic strategies targeting them to enhance the efficacy of cancer immunotherapies.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Discovery medicine MEDICINE, RESEARCH & EXPERIMENTAL-

CiteScore

5.40

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Discovery Medicine publishes novel, provocative ideas and research findings that challenge conventional notions about disease mechanisms, diagnosis, treatment, or any of the life sciences subjects. It publishes cutting-edge, reliable, and authoritative information in all branches of life sciences but primarily in the following areas: Novel therapies and diagnostics (approved or experimental); innovative ideas, research technologies, and translational research that will give rise to the next generation of new drugs and therapies; breakthrough understanding of mechanism of disease, biology, and physiology; and commercialization of biomedical discoveries pertaining to the development of new drugs, therapies, medical devices, and research technology.