Francisco Alves de Sousa , Rodrigo Pinto Costa , Sandra Xará , Ana Nóbrega Pinto , Cecília Almeida e Sousa
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Patients with COVID-19 showed worse mean auditory thresholds starting from 1000 Hz through higher frequencies, when compared to controls (<u>1000 Hz</u>: 18.52 ± 5.49 dB HL in controls vs 25.36 ± 6.79 dB HL in COVID-19, p < 0.001; <u>2000Hz</u>: 17.50 ± 5.57 dB HL in controls vs 21.96 ± 7.05 dB HL in COVID-19, p = 0.010; <u>3000Hz</u>: 17.97 ± 8.07 dB HL in controls vs 25 ± 9.38 dB HL in COVID-19, p = 0.003; <u>4000 Hz</u>: 20.16 ± 10.12 dB HL in controls vs 29.55 ± 11.26 dB HL in COVID-19, p = 0.001; <u>8000 Hz</u>: 31.09 ± 12.75 dB HL in controls vs 40.71 ± 19.40 dB HL in COVID-19, p = 0.030; <em><u>Pure Tone Average</u></em>: 20.42 ± 4.29 dB HL in controls vs 24.85 ± 5.62 dB HL in COVID-19, p = 0.001). Statistical significance persisted after adjusting for confounders such as age, gender and various comorbidities (p < 0.05).</p></div><div><h3>Conclusions</h3><p>SARS-CoV-2 may affect hearing in COVID-19 patients with moderate-severe disease. Results are in line with the previous suggested effects of COVID-19 on auditory system. This study is expected to encourage further research on this topic.</p></div>","PeriodicalId":37466,"journal":{"name":"Journal of Otology","volume":null,"pages":null},"PeriodicalIF":1.4000,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.joto.2021.01.005","citationCount":"22","resultStr":"{\"title\":\"SARS-CoV-2 and hearing: An audiometric analysis of COVID-19 hospitalized patients\",\"authors\":\"Francisco Alves de Sousa , Rodrigo Pinto Costa , Sandra Xará , Ana Nóbrega Pinto , Cecília Almeida e Sousa\",\"doi\":\"10.1016/j.joto.2021.01.005\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Purpose</h3><p>COVID-19 associated hearing loss is still an ongoing matter of debate. No original studies exist on audiological effects of SARS-CoV-2 infection in hospitalized patients. The main objective was to determine whether SARS-CoV-2 may affect auditory function in clinically ill COVID-19 patients.</p></div><div><h3>Materials and methods</h3><p>COVID-19 patients with moderate-severe disease and without prior history of hearing abnormalities were enrolled from a tertiary referral center, and matched with controls. Participants performed an audiometric evaluation, and thresholds were compared.</p></div><div><h3>Results</h3><p>120 ears from 60 patients were enrolled. Patients with COVID-19 showed worse mean auditory thresholds starting from 1000 Hz through higher frequencies, when compared to controls (<u>1000 Hz</u>: 18.52 ± 5.49 dB HL in controls vs 25.36 ± 6.79 dB HL in COVID-19, p < 0.001; <u>2000Hz</u>: 17.50 ± 5.57 dB HL in controls vs 21.96 ± 7.05 dB HL in COVID-19, p = 0.010; <u>3000Hz</u>: 17.97 ± 8.07 dB HL in controls vs 25 ± 9.38 dB HL in COVID-19, p = 0.003; <u>4000 Hz</u>: 20.16 ± 10.12 dB HL in controls vs 29.55 ± 11.26 dB HL in COVID-19, p = 0.001; <u>8000 Hz</u>: 31.09 ± 12.75 dB HL in controls vs 40.71 ± 19.40 dB HL in COVID-19, p = 0.030; <em><u>Pure Tone Average</u></em>: 20.42 ± 4.29 dB HL in controls vs 24.85 ± 5.62 dB HL in COVID-19, p = 0.001). Statistical significance persisted after adjusting for confounders such as age, gender and various comorbidities (p < 0.05).</p></div><div><h3>Conclusions</h3><p>SARS-CoV-2 may affect hearing in COVID-19 patients with moderate-severe disease. 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引用次数: 22
摘要
covid -19相关的听力损失仍然是一个持续争论的问题。目前尚无关于SARS-CoV-2感染对住院患者听力学影响的原始研究。主要目的是确定SARS-CoV-2是否会影响临床COVID-19患者的听觉功能。材料和方法从三级转诊中心招募无听力异常史的中重度scovid -19患者，并与对照组配对。参与者进行听力评估，并比较阈值。结果纳入60例患者的120耳。与对照组相比，COVID-19患者从1000 Hz到更高频率的平均听觉阈值更差(1000 Hz:对照组为18.52±5.49 dB HL，而COVID-19患者为25.36±6.79 dB HL, p <0.001;2000Hz:对照组17.50±5.57 dB HL vs新冠肺炎患者21.96±7.05 dB HL, p = 0.010;3000Hz:对照组17.97±8.07 dB HL vs新冠肺炎患者25±9.38 dB HL, p = 0.003;4000 Hz:对照组20.16±10.12 dB HL vs COVID-19患者29.55±11.26 dB HL, p = 0.001;8000hz:对照组31.09±12.75 dB HL vs COVID-19患者40.71±19.40 dB HL, p = 0.030;纯音平均值:对照组20.42±4.29 dB HL vs新冠肺炎患者24.85±5.62 dB HL, p = 0.001)。在调整了年龄、性别和各种合并症等混杂因素后，统计显著性仍然存在(p <0.05)。结论sars - cov -2可能影响COVID-19中重度患者的听力。结果与之前提出的COVID-19对听觉系统的影响一致。这项研究有望鼓励对这一主题的进一步研究。
SARS-CoV-2 and hearing: An audiometric analysis of COVID-19 hospitalized patients
Purpose
COVID-19 associated hearing loss is still an ongoing matter of debate. No original studies exist on audiological effects of SARS-CoV-2 infection in hospitalized patients. The main objective was to determine whether SARS-CoV-2 may affect auditory function in clinically ill COVID-19 patients.
Materials and methods
COVID-19 patients with moderate-severe disease and without prior history of hearing abnormalities were enrolled from a tertiary referral center, and matched with controls. Participants performed an audiometric evaluation, and thresholds were compared.
Results
120 ears from 60 patients were enrolled. Patients with COVID-19 showed worse mean auditory thresholds starting from 1000 Hz through higher frequencies, when compared to controls (1000 Hz: 18.52 ± 5.49 dB HL in controls vs 25.36 ± 6.79 dB HL in COVID-19, p < 0.001; 2000Hz: 17.50 ± 5.57 dB HL in controls vs 21.96 ± 7.05 dB HL in COVID-19, p = 0.010; 3000Hz: 17.97 ± 8.07 dB HL in controls vs 25 ± 9.38 dB HL in COVID-19, p = 0.003; 4000 Hz: 20.16 ± 10.12 dB HL in controls vs 29.55 ± 11.26 dB HL in COVID-19, p = 0.001; 8000 Hz: 31.09 ± 12.75 dB HL in controls vs 40.71 ± 19.40 dB HL in COVID-19, p = 0.030; Pure Tone Average: 20.42 ± 4.29 dB HL in controls vs 24.85 ± 5.62 dB HL in COVID-19, p = 0.001). Statistical significance persisted after adjusting for confounders such as age, gender and various comorbidities (p < 0.05).
Conclusions
SARS-CoV-2 may affect hearing in COVID-19 patients with moderate-severe disease. Results are in line with the previous suggested effects of COVID-19 on auditory system. This study is expected to encourage further research on this topic.
期刊介绍：
Journal of Otology is an open access, peer-reviewed journal that publishes research findings from disciplines related to both clinical and basic science aspects of auditory and vestibular system and diseases of the ear. This journal welcomes submissions describing original experimental research that may improve our understanding of the mechanisms underlying problems of basic or clinical significance and treatment of patients with disorders of the auditory and vestibular systems. In addition to original papers the journal also offers invited review articles on current topics written by leading experts in the field. The journal is of primary importance for all scientists and practitioners interested in audiology, otology and neurotology, auditory neurosciences and related disciplines. Journal of Otology welcomes contributions from scholars in all countries and regions across the world.
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