父系应激在后代发育和疾病中的表观遗传机制。

IF 2.6 4区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

International Journal of Genomics Pub Date : 2021-01-19 eCollection Date: 2021-01-01 DOI:10.1155/2021/6632719

Xingyun Xu, Zhigang Miao, Miao Sun, Bo Wan

{"title":"父系应激在后代发育和疾病中的表观遗传机制。","authors":"Xingyun Xu, Zhigang Miao, Miao Sun, Bo Wan","doi":"10.1155/2021/6632719","DOIUrl":null,"url":null,"abstract":"The major biological function of the sperm cell is to transmit the paternal genetic and epigenetic information to the embryo as well as the following offspring. Sperm has a unique epigenome. An increasing body of epidemiological study supports that paternal stress induced by environmental exposures and lifestyle can modulate the sperm epigenome (including histone modification, DNA methylation, and noncoding RNA expression), sperm-egg fusion, embryo development, and offspring health. Based on the existing literature, we have summarized the paternal exposure on sperm epigenome along with the representative phenotypes of offspring and the possible mechanism involved.","PeriodicalId":13988,"journal":{"name":"International Journal of Genomics","volume":"2021 ","pages":"6632719"},"PeriodicalIF":2.6000,"publicationDate":"2021-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7837765/pdf/","citationCount":"12","resultStr":"{\"title\":\"Epigenetic Mechanisms of Paternal Stress in Offspring Development and Diseases.\",\"authors\":\"Xingyun Xu, Zhigang Miao, Miao Sun, Bo Wan\",\"doi\":\"10.1155/2021/6632719\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The major biological function of the sperm cell is to transmit the paternal genetic and epigenetic information to the embryo as well as the following offspring. Sperm has a unique epigenome. An increasing body of epidemiological study supports that paternal stress induced by environmental exposures and lifestyle can modulate the sperm epigenome (including histone modification, DNA methylation, and noncoding RNA expression), sperm-egg fusion, embryo development, and offspring health. Based on the existing literature, we have summarized the paternal exposure on sperm epigenome along with the representative phenotypes of offspring and the possible mechanism involved.\",\"PeriodicalId\":13988,\"journal\":{\"name\":\"International Journal of Genomics\",\"volume\":\"2021 \",\"pages\":\"6632719\"},\"PeriodicalIF\":2.6000,\"publicationDate\":\"2021-01-19\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7837765/pdf/\",\"citationCount\":\"12\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of Genomics\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://doi.org/10.1155/2021/6632719\",\"RegionNum\":4,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2021/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q3\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Genomics","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1155/2021/6632719","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2021/1/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}

引用次数: 12

摘要

精子细胞的主要生物学功能是将父本遗传和表观遗传信息传递给胚胎及其后代。精子具有独特的表观基因组。越来越多的流行病学研究支持由环境暴露和生活方式引起的父亲压力可以调节精子表观基因组(包括组蛋白修饰、DNA甲基化和非编码RNA表达)、精子-卵子融合、胚胎发育和后代健康。在现有文献的基础上，我们对精子表观基因组暴露的研究进展、后代的典型表型及其可能的机制进行了综述。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Epigenetic Mechanisms of Paternal Stress in Offspring Development and Diseases.

查看原文本刊更多论文

Epigenetic Mechanisms of Paternal Stress in Offspring Development and Diseases.

The major biological function of the sperm cell is to transmit the paternal genetic and epigenetic information to the embryo as well as the following offspring. Sperm has a unique epigenome. An increasing body of epidemiological study supports that paternal stress induced by environmental exposures and lifestyle can modulate the sperm epigenome (including histone modification, DNA methylation, and noncoding RNA expression), sperm-egg fusion, embryo development, and offspring health. Based on the existing literature, we have summarized the paternal exposure on sperm epigenome along with the representative phenotypes of offspring and the possible mechanism involved.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

International Journal of Genomics BIOCHEMISTRY & MOLECULAR BIOLOGY-BIOTECHNOLOGY & APPLIED MICROBIOLOGY

CiteScore

5.40

自引率

0.00%

发文量

审稿时长

17 weeks

期刊介绍： International Journal of Genomics is a peer-reviewed, Open Access journal that publishes research articles as well as review articles in all areas of genome-scale analysis. Topics covered by the journal include, but are not limited to: bioinformatics, clinical genomics, disease genomics, epigenomics, evolutionary genomics, functional genomics, genome engineering, and synthetic genomics.