Jannette Rodriguez-Pallares, Maria J. Guerra, Jose L. Labandeira-Garcia
{"title":"血管紧张素II和白细胞介素-1相互作用，增加中脑前体神经球产生多巴胺能神经元","authors":"Jannette Rodriguez-Pallares, Maria J. Guerra, Jose L. Labandeira-Garcia","doi":"10.1016/j.devbrainres.2005.06.009","DOIUrl":null,"url":null,"abstract":"<div><p>Cultures of rat mesencephalic precursors treated with interleukin-1β or angiotensin II<span><span> contained significantly more dopaminergic neurons than controls. However, simultaneous treatment with </span>angiotensin<span> II and interleukin-1β did not induce any further increase. Treatment with the angiotensin type-2 receptor antagonist PD 123319 precluded both the angiotensin- and the interleukin-induced increase. The present results indicate that angiotensin type-2 receptors and interleukin-1 cooperate to induce the dopaminergic phenotype.</span></span></p></div>","PeriodicalId":100369,"journal":{"name":"Developmental Brain Research","volume":"158 1","pages":"Pages 120-122"},"PeriodicalIF":0.0000,"publicationDate":"2005-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.devbrainres.2005.06.009","citationCount":"14","resultStr":"{\"title\":\"Angiotensin II and interleukin-1 interact to increase generation of dopaminergic neurons from neurospheres of mesencephalic precursors\",\"authors\":\"Jannette Rodriguez-Pallares, Maria J. Guerra, Jose L. Labandeira-Garcia\",\"doi\":\"10.1016/j.devbrainres.2005.06.009\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Cultures of rat mesencephalic precursors treated with interleukin-1β or angiotensin II<span><span> contained significantly more dopaminergic neurons than controls. However, simultaneous treatment with </span>angiotensin<span> II and interleukin-1β did not induce any further increase. Treatment with the angiotensin type-2 receptor antagonist PD 123319 precluded both the angiotensin- and the interleukin-induced increase. The present results indicate that angiotensin type-2 receptors and interleukin-1 cooperate to induce the dopaminergic phenotype.</span></span></p></div>\",\"PeriodicalId\":100369,\"journal\":{\"name\":\"Developmental Brain Research\",\"volume\":\"158 1\",\"pages\":\"Pages 120-122\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2005-08-08\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/j.devbrainres.2005.06.009\",\"citationCount\":\"14\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Developmental Brain Research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S016538060500180X\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Developmental Brain Research","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S016538060500180X","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Angiotensin II and interleukin-1 interact to increase generation of dopaminergic neurons from neurospheres of mesencephalic precursors
Cultures of rat mesencephalic precursors treated with interleukin-1β or angiotensin II contained significantly more dopaminergic neurons than controls. However, simultaneous treatment with angiotensin II and interleukin-1β did not induce any further increase. Treatment with the angiotensin type-2 receptor antagonist PD 123319 precluded both the angiotensin- and the interleukin-induced increase. The present results indicate that angiotensin type-2 receptors and interleukin-1 cooperate to induce the dopaminergic phenotype.
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