【幽门螺杆菌的发现史】。

Orvostorteneti kozlemenyek Pub Date : 2004-01-01
György Miklós Buzás
{"title":"【幽门螺杆菌的发现史】。","authors":"György Miklós Buzás","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>The discovery of Helicobacter pylori is one of the greatest achievements in the modern history of gastroenterology, which led to fundamental changes in our approach to the pathogenesis and treatment of peptic ulcer disease. However, the road towards accepting the role of these spiral bacteria in the pathogenesis of certain diseases of the upper digestive tract was long and marked with repeated false interpretations and misunderstandings, even when--in retrospect--many times several researchers were very near to the discovery. The first observations concerning the presence of bacteria in animal/human stomachs dates from the dawn of medical microbiology, when the bacterial etiology of some other diseases (tuberculosis, cholera, dysentery, syphilis) was ascertained. In spite of many bacteriological, experimental, biochemical and therapeutic observations, the causative role of the microorganism in the pathogenesis of peptic ulcer was not recognised even in the case of most elegant demonstrations. Sometimes, head-strong thinking and excessive belief in opinion leaders statements set back the bacterial research. The identification of Helicobacter pylori by Barry J. Marshall and J. Robert Warren in 1983 can not be, in any case, considered as serendipitous: without the endeavour, youthful curiosity, talent and ambition of the former and solid classical knowledge in pathology of the latter, peptic ulcer might be considered even today as an acid-related or psychosomatic disease, as it was during the past century.</p>","PeriodicalId":82240,"journal":{"name":"Orvostorteneti kozlemenyek","volume":"49 3-4","pages":"45-56"},"PeriodicalIF":0.0000,"publicationDate":"2004-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"[History of the discovery of Helicobacter pylori].\",\"authors\":\"György Miklós Buzás\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The discovery of Helicobacter pylori is one of the greatest achievements in the modern history of gastroenterology, which led to fundamental changes in our approach to the pathogenesis and treatment of peptic ulcer disease. However, the road towards accepting the role of these spiral bacteria in the pathogenesis of certain diseases of the upper digestive tract was long and marked with repeated false interpretations and misunderstandings, even when--in retrospect--many times several researchers were very near to the discovery. The first observations concerning the presence of bacteria in animal/human stomachs dates from the dawn of medical microbiology, when the bacterial etiology of some other diseases (tuberculosis, cholera, dysentery, syphilis) was ascertained. In spite of many bacteriological, experimental, biochemical and therapeutic observations, the causative role of the microorganism in the pathogenesis of peptic ulcer was not recognised even in the case of most elegant demonstrations. Sometimes, head-strong thinking and excessive belief in opinion leaders statements set back the bacterial research. The identification of Helicobacter pylori by Barry J. Marshall and J. Robert Warren in 1983 can not be, in any case, considered as serendipitous: without the endeavour, youthful curiosity, talent and ambition of the former and solid classical knowledge in pathology of the latter, peptic ulcer might be considered even today as an acid-related or psychosomatic disease, as it was during the past century.</p>\",\"PeriodicalId\":82240,\"journal\":{\"name\":\"Orvostorteneti kozlemenyek\",\"volume\":\"49 3-4\",\"pages\":\"45-56\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2004-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Orvostorteneti kozlemenyek\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Orvostorteneti kozlemenyek","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

摘要

幽门螺杆菌的发现是现代胃肠病学史上最伟大的成就之一,它导致了我们对消化性溃疡发病机制和治疗方法的根本改变。然而,接受这些螺旋细菌在上消化道某些疾病发病机制中的作用的道路是漫长的,并且伴随着反复的错误解释和误解,即使在回顾过去时,许多研究人员都非常接近发现。关于动物/人类胃中存在细菌的第一次观察可以追溯到医学微生物学的曙光,当时确定了一些其他疾病(结核病、霍乱、痢疾、梅毒)的细菌病因。尽管进行了许多细菌学、实验、生化和治疗方面的观察,微生物在消化性溃疡发病机制中的致病作用即使在最优雅的证明中也没有得到承认。有时,固执的想法和对意见领袖言论的过度相信会阻碍细菌研究。Barry J. Marshall和J. Robert Warren在1983年发现幽门螺杆菌,无论如何都不能被认为是偶然的:如果没有前者的努力、年轻时的好奇心、才华和雄心,以及后者在病理学方面扎实的经典知识,消化性溃疡即使在今天也可能被认为是一种与酸有关的或身心疾病,就像上个世纪一样。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[History of the discovery of Helicobacter pylori].

The discovery of Helicobacter pylori is one of the greatest achievements in the modern history of gastroenterology, which led to fundamental changes in our approach to the pathogenesis and treatment of peptic ulcer disease. However, the road towards accepting the role of these spiral bacteria in the pathogenesis of certain diseases of the upper digestive tract was long and marked with repeated false interpretations and misunderstandings, even when--in retrospect--many times several researchers were very near to the discovery. The first observations concerning the presence of bacteria in animal/human stomachs dates from the dawn of medical microbiology, when the bacterial etiology of some other diseases (tuberculosis, cholera, dysentery, syphilis) was ascertained. In spite of many bacteriological, experimental, biochemical and therapeutic observations, the causative role of the microorganism in the pathogenesis of peptic ulcer was not recognised even in the case of most elegant demonstrations. Sometimes, head-strong thinking and excessive belief in opinion leaders statements set back the bacterial research. The identification of Helicobacter pylori by Barry J. Marshall and J. Robert Warren in 1983 can not be, in any case, considered as serendipitous: without the endeavour, youthful curiosity, talent and ambition of the former and solid classical knowledge in pathology of the latter, peptic ulcer might be considered even today as an acid-related or psychosomatic disease, as it was during the past century.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信