新生大鼠6-OHDA损伤后成人内侧前额皮质5 -羟色胺能神经支配减少

Miles Gregory Cunningham , Caroline Martine Connor , Kehong Zhang , Francine Mary Benes
{"title":"新生大鼠6-OHDA损伤后成人内侧前额皮质5 -羟色胺能神经支配减少","authors":"Miles Gregory Cunningham ,&nbsp;Caroline Martine Connor ,&nbsp;Kehong Zhang ,&nbsp;Francine Mary Benes","doi":"10.1016/j.devbrainres.2005.02.020","DOIUrl":null,"url":null,"abstract":"<div><p>The development of the serotonergic (5HT) and dopaminergic (DA) systems may contribute to the onset of psychotic disorders during late adolescence and early adulthood. Previous studies in our laboratory have suggested that these systems may compete for functional territory on neurons during development, as lesions of the serotonergic system at postnatal day 5 (P5) result in an increase in the density of dopaminergic fibers in rat medial prefrontal cortex (mPFC). In the present study, the dopaminergic system of P5 rats was lesioned with intracisternal injections of 6-hydroxydopamine (6-OHDA). Quantification of serotonin-immunoreactivity (5HT-IR) in mPFC at adulthood (P70) revealed a significant decrease in fiber density within layers II and III of the Cg3 subdivision of mPFC in lesioned rats compared to sham controls. We propose that the decrease in serotonergic fibers in mPFC in response to a neonatal depletion of dopamine may be due to the loss of a trophic effect of this system on 5HT neurons and/or fibers during development. Taken together with previous findings, our data suggest that there may be an “inverse trophic” relationship between the cortical DA and 5HT systems whereby dopamine facilitates the ingrowth of 5HT fibers, while serotonin suppresses the ingrowth of DA fibers. We present a model based on neurotrophic interactions at the cortical and brainstem levels that could potentially explain these unexpected results.</p></div>","PeriodicalId":100369,"journal":{"name":"Developmental Brain Research","volume":"157 2","pages":"Pages 124-131"},"PeriodicalIF":0.0000,"publicationDate":"2005-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.devbrainres.2005.02.020","citationCount":"19","resultStr":"{\"title\":\"Diminished serotonergic innervation of adult medial prefrontal cortex after 6-OHDA lesions in the newborn rat\",\"authors\":\"Miles Gregory Cunningham ,&nbsp;Caroline Martine Connor ,&nbsp;Kehong Zhang ,&nbsp;Francine Mary Benes\",\"doi\":\"10.1016/j.devbrainres.2005.02.020\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>The development of the serotonergic (5HT) and dopaminergic (DA) systems may contribute to the onset of psychotic disorders during late adolescence and early adulthood. Previous studies in our laboratory have suggested that these systems may compete for functional territory on neurons during development, as lesions of the serotonergic system at postnatal day 5 (P5) result in an increase in the density of dopaminergic fibers in rat medial prefrontal cortex (mPFC). In the present study, the dopaminergic system of P5 rats was lesioned with intracisternal injections of 6-hydroxydopamine (6-OHDA). Quantification of serotonin-immunoreactivity (5HT-IR) in mPFC at adulthood (P70) revealed a significant decrease in fiber density within layers II and III of the Cg3 subdivision of mPFC in lesioned rats compared to sham controls. We propose that the decrease in serotonergic fibers in mPFC in response to a neonatal depletion of dopamine may be due to the loss of a trophic effect of this system on 5HT neurons and/or fibers during development. Taken together with previous findings, our data suggest that there may be an “inverse trophic” relationship between the cortical DA and 5HT systems whereby dopamine facilitates the ingrowth of 5HT fibers, while serotonin suppresses the ingrowth of DA fibers. We present a model based on neurotrophic interactions at the cortical and brainstem levels that could potentially explain these unexpected results.</p></div>\",\"PeriodicalId\":100369,\"journal\":{\"name\":\"Developmental Brain Research\",\"volume\":\"157 2\",\"pages\":\"Pages 124-131\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2005-06-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/j.devbrainres.2005.02.020\",\"citationCount\":\"19\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Developmental Brain Research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0165380605000751\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Developmental Brain Research","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0165380605000751","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 19

摘要

5 -羟色胺能(5HT)和多巴胺能(DA)系统的发展可能有助于青春期晚期和成年早期精神病的发病。我们实验室之前的研究表明,这些系统可能在发育过程中争夺神经元的功能领域,因为在出生后第5天(P5),血清素能系统的损伤导致大鼠内侧前额叶皮层(mPFC)中多巴胺能纤维的密度增加。本研究通过腹腔注射6-羟基多巴胺(6-OHDA)损伤P5大鼠的多巴胺能系统。成年期mPFC (P70)的血清素免疫反应性(5HT-IR)定量显示,与假对照组相比,受损大鼠mPFC Cg3细分的第II层和第III层纤维密度显著降低。我们认为新生儿多巴胺耗竭后mPFC中血清素能纤维的减少可能是由于该系统在发育过程中对5HT神经元和/或纤维的营养作用的丧失。结合之前的研究结果,我们的数据表明皮层DA和5HT系统之间可能存在“逆营养”关系,即多巴胺促进5HT纤维的长入,而血清素抑制DA纤维的长入。我们提出了一个基于皮层和脑干水平的神经营养相互作用的模型,可以潜在地解释这些意想不到的结果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Diminished serotonergic innervation of adult medial prefrontal cortex after 6-OHDA lesions in the newborn rat

The development of the serotonergic (5HT) and dopaminergic (DA) systems may contribute to the onset of psychotic disorders during late adolescence and early adulthood. Previous studies in our laboratory have suggested that these systems may compete for functional territory on neurons during development, as lesions of the serotonergic system at postnatal day 5 (P5) result in an increase in the density of dopaminergic fibers in rat medial prefrontal cortex (mPFC). In the present study, the dopaminergic system of P5 rats was lesioned with intracisternal injections of 6-hydroxydopamine (6-OHDA). Quantification of serotonin-immunoreactivity (5HT-IR) in mPFC at adulthood (P70) revealed a significant decrease in fiber density within layers II and III of the Cg3 subdivision of mPFC in lesioned rats compared to sham controls. We propose that the decrease in serotonergic fibers in mPFC in response to a neonatal depletion of dopamine may be due to the loss of a trophic effect of this system on 5HT neurons and/or fibers during development. Taken together with previous findings, our data suggest that there may be an “inverse trophic” relationship between the cortical DA and 5HT systems whereby dopamine facilitates the ingrowth of 5HT fibers, while serotonin suppresses the ingrowth of DA fibers. We present a model based on neurotrophic interactions at the cortical and brainstem levels that could potentially explain these unexpected results.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信