{"title":"螺旋线圈的结构。","authors":"Andrei N Lupas, Markus Gruber","doi":"10.1016/S0065-3233(05)70003-6","DOIUrl":null,"url":null,"abstract":"<p><p>alpha-Helical coiled coils are versatile protein domains, supporting a wide range of biological functions. Their fold is probably better understood than that of any other protein; indeed, uniquely among folds, their structure can be computed from a set of parametric equations. Here, we review the principles of coiled-coil structure, the determinants of their folding and stability, and the diversity of structural forms they assume.</p>","PeriodicalId":51216,"journal":{"name":"Advances in Protein Chemistry","volume":"70 ","pages":"37-78"},"PeriodicalIF":0.0000,"publicationDate":"2005-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0065-3233(05)70003-6","citationCount":"561","resultStr":"{\"title\":\"The structure of alpha-helical coiled coils.\",\"authors\":\"Andrei N Lupas, Markus Gruber\",\"doi\":\"10.1016/S0065-3233(05)70003-6\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>alpha-Helical coiled coils are versatile protein domains, supporting a wide range of biological functions. Their fold is probably better understood than that of any other protein; indeed, uniquely among folds, their structure can be computed from a set of parametric equations. Here, we review the principles of coiled-coil structure, the determinants of their folding and stability, and the diversity of structural forms they assume.</p>\",\"PeriodicalId\":51216,\"journal\":{\"name\":\"Advances in Protein Chemistry\",\"volume\":\"70 \",\"pages\":\"37-78\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2005-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/S0065-3233(05)70003-6\",\"citationCount\":\"561\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Advances in Protein Chemistry\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1016/S0065-3233(05)70003-6\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advances in Protein Chemistry","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1016/S0065-3233(05)70003-6","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
alpha-Helical coiled coils are versatile protein domains, supporting a wide range of biological functions. Their fold is probably better understood than that of any other protein; indeed, uniquely among folds, their structure can be computed from a set of parametric equations. Here, we review the principles of coiled-coil structure, the determinants of their folding and stability, and the diversity of structural forms they assume.
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