Satoshi Nagamine, Seiichi Koike, Kazuko Keino-Masu, Masayuki Masu
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引用次数: 39
摘要
一类新的磺化酶，SulfFP1/sulf-1和SulfFP2/sulf-2，通过6- o -氨基磺化酶活性重塑硫酸肝素，参与细胞外信号的调节。本研究分离大鼠SulfFP2 cDNA，通过原位杂交检测其表达。SulfFP2在发育过程中在神经系统中表达丰富且受动态调控，而在成人大脑中则局限于大脑皮层、海马CA3区和内侧缰核。
Expression of a heparan sulfate remodeling enzyme, heparan sulfate 6-O-endosulfatase sulfatase FP2, in the rat nervous system
A new class of sulfatases, SulfFP1/sulf-1 and SulfFP2/sulf-2, has been implicated in the modulation of extracellular signaling by remodeling heparan sulfate through 6-O-endosulfatase activity. Here, we isolated rat SulfFP2 cDNA and examined its expression by in situ hybridization. SulfFP2 expression is abundant and dynamically regulated in the nervous system during development, whereas it is confined to the cerebral cortex, hippocampal CA3 region, and medial habenular nucleus in the adult brain.
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