生物圈2号机组人员对热量限制和慢性缺氧的非典型血液学反应:可能与冬眠能力的潜在特征有关。

Donald E Paglia, Roy L Walford
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引用次数: 9

摘要

8个人被隔离在生物圈2号中2年,这是一个密封的栖息地,有可循环的空气、食物、水和废物。这些条件的结合导致内部大气中的氧气(O2)选择性地从21%下降到14%,引起高原反应的症状,但红细胞生成很少或没有代偿性增加。所有机组人员的红细胞2,3-双磷酸甘油酸(2,3- bpg)浓度和P50[50%血红蛋白(Hb)饱和度O2分压]值均显著下降,这与适应高海拔缺氧的预期变化相反。低2,3- bpg诱导的P50降低和Hb-O2亲和力增加是冬眠物种的特征,在o2缺乏的环境中可能是有利的。生物圈2号船员中这些变化的机制尚不清楚,但可能与低热量饮食(1750-2100千卡/天)有关。由于缺氧和有限热量摄入的结合也是冬眠的特征,这种不寻常的反应可能代表了一种交叉适应现象,在这种现象中,人类表达了冬眠能力的某些特征。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Atypical hematological response to combined calorie restriction and chronic hypoxia in Biosphere 2 crew: a possible link to latent features of hibernation capacity.

Eight humans were isolated for 2 years in Biosphere 2, a sealed airtight habitat with recycled air, food, water, and wastes. A combination of conditions led to selective decline of oxygen (O2) in the internal atmosphere from 21% to 14%, inducing symptoms of high-altitude sickness but with little or no compensatory increase in red cell production. All crew members exhibited significant decreases in both erythrocyte 2,3-bisphosphoglycerate (2,3-BPG) concentrations and P50 [partial pressure of O2 for 50% hemoglobin (Hb) saturation] values, changes opposite those expected in adaptation to high-altitude hypoxia. Lower P50 with increased Hb-O2 affinity induced by low 2,3-BPG is a characteristic of hibernating species and could be advantageous in O2-impoverished environments. The mechanisms underlying these changes in the Biosphere 2 crew remain obscure but could be related to low-calorie diet (1750-2100 kcal/day). Because the combination of hypoxia and limited caloric intake is also characteristic of hibernation, this unusual response may represent a cross-adaptation phenomenon in which certain features of hibernation capability are expressed in humans.

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