{"title":"Bk(Ca)通道活性随豚鼠膀胱平滑肌肌肉拉伸而增强。","authors":"Yoshio Tanaka, Takao Okamoto, Toshiyasu Imai, Yoshihisa Yamamoto, Takahiro Horinouchi, Hikaru Tanaka, Katsuo Koike, Koki Shigenobu","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Possible effects of muscle stretch on the spontaneous rhythmic contractile activity and the extent of contribution of voltage-dependent and Ca2+ -activated K+ (BK(Ca)) channels were examined mechanically in guinea-pig urinary bladder smooth muscle (UBSM). The amplitude of the spontaneous mechanical activity showed stretch-dependency. Iberiotoxin, a selective blocker of BK(Ca) channels, potently increased contraction amplitude, and this effect was more prominent when muscle length was more than twice of its initial length. BK(Ca) channels seem activated more strongly to counteract enhanced spontaneous mechanical activity with UBSM stretch.</p>","PeriodicalId":21045,"journal":{"name":"Research communications in molecular pathology and pharmacology","volume":"113-114 ","pages":"247-52"},"PeriodicalIF":0.0000,"publicationDate":"2003-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Bk(Ca) channel activity enhances with muscle stretch in guinea-pig urinary bladder smooth muscle.\",\"authors\":\"Yoshio Tanaka, Takao Okamoto, Toshiyasu Imai, Yoshihisa Yamamoto, Takahiro Horinouchi, Hikaru Tanaka, Katsuo Koike, Koki Shigenobu\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Possible effects of muscle stretch on the spontaneous rhythmic contractile activity and the extent of contribution of voltage-dependent and Ca2+ -activated K+ (BK(Ca)) channels were examined mechanically in guinea-pig urinary bladder smooth muscle (UBSM). The amplitude of the spontaneous mechanical activity showed stretch-dependency. Iberiotoxin, a selective blocker of BK(Ca) channels, potently increased contraction amplitude, and this effect was more prominent when muscle length was more than twice of its initial length. BK(Ca) channels seem activated more strongly to counteract enhanced spontaneous mechanical activity with UBSM stretch.</p>\",\"PeriodicalId\":21045,\"journal\":{\"name\":\"Research communications in molecular pathology and pharmacology\",\"volume\":\"113-114 \",\"pages\":\"247-52\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2003-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Research communications in molecular pathology and pharmacology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Research communications in molecular pathology and pharmacology","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Bk(Ca) channel activity enhances with muscle stretch in guinea-pig urinary bladder smooth muscle.
Possible effects of muscle stretch on the spontaneous rhythmic contractile activity and the extent of contribution of voltage-dependent and Ca2+ -activated K+ (BK(Ca)) channels were examined mechanically in guinea-pig urinary bladder smooth muscle (UBSM). The amplitude of the spontaneous mechanical activity showed stretch-dependency. Iberiotoxin, a selective blocker of BK(Ca) channels, potently increased contraction amplitude, and this effect was more prominent when muscle length was more than twice of its initial length. BK(Ca) channels seem activated more strongly to counteract enhanced spontaneous mechanical activity with UBSM stretch.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
