急性髓母细胞白血病中与双分钟染色体和MYC扩增相关的4三体

Annales de Génétique Pub Date : 2004-10-01 DOI:10.1016/j.anngen.2004.08.004

Aline Receveur , Jeanne Ong , Laurent Merlin , Zahia Azgui , Hélène Merle-Béral , Roland Berger , Florence Nguyen-Khac

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引用次数: 12

摘要

报告1例新发急性髓母细胞白血病(AML) M2，伴4三体和双分钟(dmin)染色体。FISH证实MYC基因扩增与dmin有关。对4-dmin三体相关AML的文献回顾表明，这种实体优先发生在老年女性中，并不总是与先前确定的突变剂暴露有关。

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Trisomy 4 associated with double minute chromosomes and MYC amplification in acute myeloblastic leukemia

A case of de novo acute myeloblastic leukemia (AML) M2, with trisomy 4 and double minute (dmin) chromosomes is reported. Amplification of the MYC gene ascertained by FISH was associated with dmin. A review of the literature of trisomy 4-dmin-associated AML shows that this entity preferentially occurs in elderly women and is not always associated with previously identified exposition to mutagens.

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Annales de Génétique

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