{"title":"葡萄糖两步法合成熊果苷的研究。","authors":"Shen-Lin Huang, Yu-Lin Zhu, Yuan-Jiang Pan, Shi-Hua Wu","doi":"10.1631/jzus.2004.1509","DOIUrl":null,"url":null,"abstract":"<p><p>Arbutin was synthesized from glucose by two-step reaction below: (a) 2,3,4,6-tetra-O-acetyl-alpha-D-glucosyl chloride or bromide was prepared by glucose and acetyl halide (chloride or bromide). (b) 2,3,4,6-tetra-O-acetyl-alpha-D-glucosyl halide (Cl, Br) reacted with hydroquinone, methanol as solvent at pH=9.5-10.0.</p>","PeriodicalId":85042,"journal":{"name":"Journal of Zhejiang University. Science","volume":"5 12","pages":"1509-11"},"PeriodicalIF":0.0000,"publicationDate":"2004-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1631/jzus.2004.1509","citationCount":"14","resultStr":"{\"title\":\"Synthesis of arbutin by two-step reaction from glucose.\",\"authors\":\"Shen-Lin Huang, Yu-Lin Zhu, Yuan-Jiang Pan, Shi-Hua Wu\",\"doi\":\"10.1631/jzus.2004.1509\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Arbutin was synthesized from glucose by two-step reaction below: (a) 2,3,4,6-tetra-O-acetyl-alpha-D-glucosyl chloride or bromide was prepared by glucose and acetyl halide (chloride or bromide). (b) 2,3,4,6-tetra-O-acetyl-alpha-D-glucosyl halide (Cl, Br) reacted with hydroquinone, methanol as solvent at pH=9.5-10.0.</p>\",\"PeriodicalId\":85042,\"journal\":{\"name\":\"Journal of Zhejiang University. Science\",\"volume\":\"5 12\",\"pages\":\"1509-11\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2004-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1631/jzus.2004.1509\",\"citationCount\":\"14\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Zhejiang University. Science\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1631/jzus.2004.1509\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Zhejiang University. Science","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1631/jzus.2004.1509","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 14
摘要
以葡萄糖为原料，经两步反应合成熊果苷:(a)以葡萄糖和乙酰卤化物(氯或溴)为原料，制备2,3,4,6-四- o-乙酰- d -葡萄糖酰氯或溴。(b) 2,3,4,6-四- o -乙酰- α - d -葡萄糖基卤化物(Cl, Br)在pH=9.5-10.0条件下与对苯二酚、甲醇反应。
Synthesis of arbutin by two-step reaction from glucose.
Arbutin was synthesized from glucose by two-step reaction below: (a) 2,3,4,6-tetra-O-acetyl-alpha-D-glucosyl chloride or bromide was prepared by glucose and acetyl halide (chloride or bromide). (b) 2,3,4,6-tetra-O-acetyl-alpha-D-glucosyl halide (Cl, Br) reacted with hydroquinone, methanol as solvent at pH=9.5-10.0.
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