超重和肥胖西班牙青少年的炎症介质。AVENA研究。

J Wärnberg, L A Moreno, M I Mesana, A Marcos
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引用次数: 71

摘要

目的:本研究的目的是澄清是否有超重和青少年慢性,低度炎症状态之间的联系。设计:本研究是横断面多中心研究AVENA的一部分,旨在评估西班牙青少年代表性样本的营养状况。根据国际肥胖工作组(IOTF)的标准,将青少年分为两组:(1)非超重组和(2)超重/肥胖组。研究对象:AVENA研究的一个具有地理代表性的亚样本,包括493名13-18岁的西班牙青少年(236名女性/257名男性)参加了本研究。测量方法:测定血清c反应蛋白(CRP)、白细胞介素6和肿瘤坏死因子α的体外生成,并进行详细的人体测量。结果:炎症指标在超重/肥胖组普遍高于非超重组,只有CRP有显著差异(非超重组和超重/肥胖组的平均值分别为0.83和1.27 mg/l)。结论:虽然我们还没有研究青少年超重和肥胖是否在未来疾病的发展中起着启动作用,但我们认为它可能导致慢性低度炎症状态,这指出了保持适当的体重对于避免成年期肥胖相关疾病的重要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Inflammatory mediators in overweight and obese Spanish adolescents. The AVENA Study.

Objective: The aim of this study was to clarify if there is an association between overweight and a state of chronic, low-grade inflammation in adolescents.

Design: The study is a part of the cross-sectional multicenter study AVENA, designed to evaluate the nutritional status of a representative sample of Spanish adolescents. The adolescents were divided into two groups: (1) nonoverweight and (2) overweight/obesity using the International Obesity Task Force (IOTF) standards.

Subjects: A geographically representative subsample of the AVENA study including 493 Spanish adolescents, aged 13-18 y (236 females/257 males), participated in this study.

Measurements: Serum C-reactive protein (CRP) and in vitro production of interleukin 6 and tumor necrosis factor alpha were measured, together with a detailed anthropometry.

Results: The inflammatory markers showed generally higher values in subjects with overweight/obesity than in those with nonoverweight, with only CRP showing significant differences (the means were 0.83 and 1.27 mg/l in the nonoverweight and overweight/obesity groups, respectively).

Conclusion: Although we have not studied if adolescent overweight and obesity play an initiating role in the development of future diseases, we suggest it may induce a chronic low-grade inflammatory state, which points out the importance of maintaining an appropriate body weight, to avoid obesity-related diseases in adulthood.

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