儿童肥胖中调节脂质代谢和血浆脂质的激素。

M Gil-Campos, R Cañete, A Gil
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引用次数: 61

摘要

目的:综述瘦素、胰岛素和脂联素影响肥胖患者脂质代谢和血脂的机制,并探讨这些激素在青春期前儿童中的相关性。方法:对近5年来发表的有关瘦素、胰岛素和脂联素相互作用的相关论文进行修订,重点关注这些激素调节脂质代谢和血脂的潜在机制。我们还提供了关于青春期前肥胖儿童血浆脂质与瘦素、胰岛素和脂联素之间关系的原始结果。结果:最近的文献资料为瘦素和脂联素在调节外周组织脂质代谢中的作用提供了新的解释。激活amp依赖性激酶途径和随后增加的脂肪酸氧化似乎是这些激素在调节脂质代谢中的主要作用机制。此外,我们发现肥胖儿童胰岛素血浆水平与瘦素呈正相关,而与脂联素呈负相关。脂联素与代谢综合征的血浆脂质标志物呈负相关,但与高密度脂蛋白胆固醇呈正相关,而胰岛素和瘦素表现出相反的模式。这些结果支持脂联素在增加胰岛素敏感性和降低血浆甘油三酯方面的作用。结论:瘦素、胰岛素和脂联素是调节儿童脂质代谢的相关激素。脂联素似乎是解释肥胖中脂质代谢和血浆脂质的改变的缺失环节。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Hormones regulating lipid metabolism and plasma lipids in childhood obesity.

Objective: To review the mechanisms by which leptin, insulin and adiponectin influence lipid metabolism and plasma lipids in obesity, as well as to describe the associations between these hormones in prepubertal children.

Method: Revision of relevant papers published in the last 5 y related to the interactions of leptin, insulin and adiponectin, with special emphasis on those reporting potential mechanisms by which these hormones regulate lipid metabolism and plasma lipids. We also provide original results concerning the relationships found between plasma lipids and leptin, and insulin and adiponectin in prepubertal obese children.

Results: Recent data in the literature shed new light to explain the effects of both leptin and adiponectin in the regulation of lipid metabolism in peripheral tissues. Activation of the AMP-dependent kinase pathway and subsequent increased fatty acid oxidation seems to be the main mechanism of action of these hormones in the regulation of lipid metabolism. In addition, we have found that insulin plasma levels are positively associated to leptin but negatively correlated with adiponectin in obese children. Adiponectin is negatively associated to plasma lipid markers of metabolic syndrome but positively related to HDL-cholesterol, whereas insulin and leptin show opposite patterns. These results support the effect of adiponectin in increasing insulin sensitivity and decreasing plasma triglycerides.

Conclusion: Leptin, insulin and adiponectin are associated hormones that regulate lipid metabolism in childhood. Adiponectin appears to be the missing link to explain the alterations in lipid metabolism and plasma lipids seen in obesity.

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