盐酸尼非卡兰特治疗缺血性心肌病合并严重室性功能障碍1例。

Kiyokazu Kokaji, Masahiko Okamoto, Kentaro Hotoda, Hiroya Kumamaru
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引用次数: 3

摘要

52岁男性缺血性心肌病合并严重心室功能障碍患者行冠状动脉旁路移植术及左心室重建术(Dor手术)。患者术后早期出现急性发作的不间断室性心动过速,I类抗心律失常药物治疗难治性,需要多次尝试电复律。静脉注射盐酸尼非卡兰特和肠内胺碘酮联合治疗这种复发性不间断室性心动过速。盐酸尼非卡兰特作为负荷剂量(0.3 mg/kg/5 min),然后静脉输注(0.4 mg/kg/hr)。开始治疗几天后,患者不再经历室性心动过速发作,血流动力学也没有受损。我们得出结论,盐酸尼非卡兰特是抑制严重左心室功能障碍患者室性心动过速的有效药物,特别是在术后早期。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Experience with nifekalant hydrochloride in a patient with ischemic cardiomyopathy and severe ventricular dysfunction after dor operation.

A 52-year-old male with ischemic cardiomyopathy and severe ventricular dysfunction underwent coronary artery bypass grafting and left ventricular reconstruction (Dor operation). The patient developed acute onset of incessant ventricular tachycardia in the early postoperative period that was refractory to therapy with class I antiarrhythmic agents, and multiple attempts at electrical cardioversion were required. A combination of intravenous nifekalant hydrochloride and enteral amiodarone was elected as treatment for this recurrent incessant ventricular tachycardia. Nifekalant hydrochloride was administered as a loading dose (0.3 mg/kg/5 min), followed by an intravenous infusion (0.4 mg/kg/hr). Several days after initiating therapy, the patient no longer experienced episodes of ventricular tachycardia, and there was no compromise in hemodynamics. We conclude that nifekalant hydrochloride is a useful agent for suppression of ventricular tachycardia in patients with severe left ventricular dysfunction, especially during the early postoperative period.

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