向德克萨斯州毒物中心报告的育龄妇女和孕妇的暴露和治疗。

Veterinary and human toxicology Pub Date : 2004-08-01
Mathias B Forrester, Sharilyn K Stanley
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引用次数: 0

摘要

中毒中心报告的两次暴露和使用的治疗都涉及潜在的致畸物。这项调查描述了2000-2002年期间向德克萨斯州中毒中心报告的育龄妇女和孕妇的暴露和治疗模式。在报告的476,365例人类暴露中,65,074例(13.7%)涉及育龄妇女,1,406例(0.3%)涉及孕妇。在育龄妇女中最常报告的暴露是镇痛药(镇静剂、催眠药、抗精神病药)和抗抑郁药。致畸物酒精和抗惊厥药分别是第5位和第13位最常报告的暴露。治疗育龄妇女最常用的药物是口服n -乙酰半胱氨酸、抗组胺药和纳洛酮;抗惊厥药是第7位最常报道的用于治疗的物质,乙醇是第28位最常报道的物质。虽然只有一小部分育龄孕妇向德克萨斯州中毒中心报告,但有一部分未怀孕的妇女可能已经怀孕,但不知道这个事实,因此可能在对致畸物最敏感的时候接触了致畸物。中毒中心在向患者提供信息和建议治疗时需要意识到这一点。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Exposures and treatments among women of childbearing age and pregnant women reported to Texas poison centers.

Both exposures reported to poison centers and the treatments used involved potential teratogens. This investigation describes the patterns of exposures and treatments among women of childbearing age and pregnant women reported to Texas poison centers during 2000-2002. Of 476,365 total reported human exposures, 65,074 (13.7%) involved women of childbearing age and 1,406 (0.3%) involved pregnant women. The most frequently reported exposures among women of childbearing age were analgesics (sedatives, hypnotics, antipsychotics) and antidepressants. The teratogens alcohol and anticonvulsants were the 5th and 13th most frequently reported exposures, respectively. The substances used most often to treat women of childbearing age were oral N-acetylcysteine, antihistamines and naloxone; anticonvulsants were the 7th most frequently reported substance used in treatment, and ethanol the 28th most commonly reported substance. Although only a small fraction of pregnant women of childbearing age reported to Texas poison centers, a portion of women reported to be not pregnant may have been pregnant and unaware of the fact, and thus may have been exposed to a teratogen at a time when susceptibility to teratogens is greatest. Poison centers need to be aware of this when providing information to patients and recommending treatment.

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