“超低”剂量纳曲酮和吗啡在成年和年轻雄性和雌性大鼠中的相互作用。

Scott R Hamann, Hammad Malik, Jewell W Sloan, Elzbieta P Wala
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引用次数: 18

摘要

性别和年龄对人类和动物吗啡镇痛的影响。成年大鼠雄性吗啡镇痛作用大于雌性。超低剂量纳曲酮增强吗啡镇痛。在成年大鼠(18-22周)中,纳曲酮(0.002-2.0 mg/kg)-吗啡(2 mg/kg)共处理可增强雌性吗啡镇痛,其效果与纳曲酮剂量呈负相关。相反,在成年雄性大鼠中,纳曲酮随着剂量的增加有减少吗啡镇痛的趋势。在幼龄大鼠(8-10周)中,吗啡镇痛与性别无关,在两性中,纳曲酮与吗啡的相互作用可以忽略不计。这些数据表明,剂量、年龄和性别会改变大鼠的纳曲酮-吗啡相互作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Interactions of "ultra-low" doses of naltrexone and morphine in mature and young male and female rats.

Sex and age influence morphine analgesia in humans and animals. Mature rats show greater morphine analgesia in males than in females. Ultra-low doses of naltrexone enhance morphine analgesia. In mature rats (18-22 weeks), naltrexone (0.002-2.0 mg/kg)-morphine (2 mg/kg) cotreatment enhanced morphine analgesia in females, an effect inversely related to naltrexone dose. Conversely, in mature male rats, naltrexone tended to decrease morphine analgesia with increasing dose. In young rats (8-10 weeks), morphine analgesia was unrelated to sex and in both sexes the naltrexone-morphine interaction was negligible. These data show that dose, age, and sex alter the naltrexone-morphine interaction in rats.

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