蜜蜂毒液毒性作用对肾上腺皮质超微结构的影响。

A Rodríguez-Acosta, J Vega, H J Finol, M Pulido-Mendez
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引用次数: 0

摘要

蜜蜂事故的发生率被低估了,因为许多人不咨询医生。本文首次报道了蜜蜂毒液对小鼠肾上腺的严重损伤。取小鼠肾上腺活检标本,样品制备后在日立H-7100电镜下观察。超微结构分析显示,注射后6 h内皮网呈非均匀光滑状,部分质膜丢失。开窗间隙增大,毛细血管腔内可见碎屑。皮质细胞中可见红细胞。注射毒液48 h后,观察开窗扩大。毛细血管基膜断裂。可见髓鞘样图形和自噬空泡。光面可见肿胀光滑的内质网元件和内皮展开。高尔基体和线粒体肿胀,部分部位形成髓样形态。注射后144h,毛细血管窗间隙变宽。细胞切片显示光滑的内质网成分肿胀和缺失。光滑内质网小管消失提示非甾体生成。综上所述,我们认为一些蜜蜂感染人类的临床表现,正如在小鼠中观察到的那样,是由这种毒液中存在的毒素产生的肾上腺上腺损伤决定的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Ultrastructural alterations in cortex of adrenal gland caused by the toxic effect of bee (Apis mellifera) venom.

Bee accidents incidence is underestimated because many people do not consult to the physicians. Here it is described for the first time the severe mice adrenal gland damage induced by Apis mellifera venom. Biopsy specimens were obtained from mice adrenal gland and after sample preparation observed in Hitachi H-7100 electron microscope. In this work the ultrastructural analysis showed, 6 h after injection, a non homogeneous smooth endothelial reticulum, and in some places loss of plasma membrane. The fenestrae spaces were bigger and detritus in the capillary lumen were observed. Erythrocytes were seen in a cortical cell. After 48 h of venom injection, expanded fenestrae were observed. Capillary basal membrane was interrupted. Myelin-like figures and autophagic vacuoles were noticed. Swollen smooth endoplasmic reticulum elements and endothelial unfolding to the light were seen. Moreover, swollen Golgi and mitochondria were observed, in some places forming myelinic-like figures. At 144 h after venom injection, widened spaces were noticed in capillary fenestrae. Cellular section showed swollen and lost smooth endoplasmic reticulum elements. Smooth endoplasmic reticulum tubules disappearance suggested non steroidogenesis. In conclusion, we suggest that some of the bee envenoming human clinical manifestations, as is observed in mice, are determined by suprarenal gland damage produced by toxins present in this venom.

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