细胞对血管内导管的反应。

L T Chen, C P Phelps, M W Bryant, M E Chen
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引用次数: 0

摘要

中心静脉导管通常用于输液治疗和全肠外营养的管理。导管阻塞是长期使用此类装置最常见的非感染性并发症。导管闭塞的原因是导管周围形成了组织套。本研究采用大鼠模型研究整合素拮抗剂肽对颈静脉导管周围组织套生长的影响。当整合素拮抗剂肽皮下注射,每天两次,3天,剂量为10 mg/kg体重/天,与注射生理盐水或对照肽的大鼠相比,组织套的生长减少了40%。组织袖的形态学研究表明,导管相关的内皮细胞损伤与血小板和白细胞粘附损伤的内皮细胞和纤维蛋白在附近的积累有关。这一建议的事件序列导致组织套筒厚度的增加和套筒透明度的变化。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Cellular response to an intravascular catheter.

Central venous catheters are commonly used in clinics for the administration of infusion therapy and total parenteral nutrition. Catheter occlusion is the most common noninfectious complication associated with the long-term use of such devices. The cause of catheter occlusion is the formation of a tissue sleeve around the catheter. In this study, a rat model was used to investigate the effects of integrin antagonist peptide on the growth of the tissue sleeve around the jugular catheters. When integrin antagonist peptide was injected subcutaneously, twice daily, for 3 days, at a dosage of 10 mg/kg of body weight/day, the growth of the tissue sleeve was reduced by 40%, as compared to rats injected with saline or control peptide. Morphological study of the tissue sleeve indicated that catheter-related damage to the nearby endothelial cells was associated with the adhesion of platelets and leukocytes to the injured endothelium and accumulation of fibrin in the vicinity. This proposed sequence of events resulted in an increase in the thickness of the tissue sleeve and changes in sleeve transparency.

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