子宫内暴露于己烯雌酚的胎儿第一代出现肢体缺损,第二代出现耳聋

C. Stoll, Y. Alembik, B. Dott
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引用次数: 18

摘要

孕妇在怀孕期间使用己烯雌酚(DES)治疗可在其女儿进入青春期或成年期时产生阴道腺癌和其他阴道异常,流产和没有足月婴儿。关于母亲接受DES治疗的新生儿畸形,女性报告了阴蒂肿大和子宫畸形,男性报告了生殖器病变。然而,主要先天性异常的频率并不比预期的高。我们报告了母亲在怀孕期间接受DES治疗的第一代儿童中有3例肢体减少缺陷(LRD),以及宫内暴露于DES后的第二代儿童中有两名儿童(一男一女)耳聋。LRD与其他先天性异常无关。患有LRD的畸形儿童是在1965年至1973年间出生的。耳聋也是孤立的。两位没有听力问题和健康的母亲分别于1963年和1965年在子宫内暴露于DES。他们的孩子分别出生于1989年和1994年。综上所述,LRD和听力损失与宫内暴露于DES可能是巧合。然而,一些假说可以解释这些关联。先天性听力损失在第二代可能提示跨代效应。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Limb reduction defects in the first generation and deafness in the second generation of intrauterine exposed fetuses to diethylstilbestrol

Maternal treatment with diethylstilbestrol (DES) during pregnancy can produce vaginal adenocarcinoma and other abnormalities of the vagina in her daughters when they reach adolescence or adulthood, miscarriages and absence of full term infants. Concerning malformations in newborns whose mothers were treated with DES, clitoromegaly and malformations of the uterus were reported in females and genital lesions in males. However, the frequencies of major congenital anomalies were not greater than expected. We report three cases of limb reduction defects (LRD) in the first generation of children whose mothers were treated with DES during pregnancy, and two children (one male, one female) with deafness in the second generation after intrauterine exposure to DES. The LRD were not associated with other congenital anomalies. The malformed children with LRD were born between 1965 and 1973. The deafness was also isolated. The two mothers who have no hearing problems and who are healthy were exposed in utero to DES in 1963 and 1965, respectively. Their children were born in 1989 and 1994, respectively. In conclusion, the association of LRD and hearing loss with intrauterine exposure to DES could be coincidental. However, some hypothesis may explain these associations. Congenital hearing loss in the second generation may suggest a transgenerational effect.

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