A Zarghi, A H Ebrahimabadi, F Hassanzadeh, M R Heydari, A Shafiee
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引用次数: 0
摘要
合成了一系列1-甲基-4-(4- x -芳基磺酰基)吡咯[2,3-d]咪唑-le-5-羧酸盐，并对其作为抗炎药进行了测试。以吲哚美辛为对照药。合成的两种化合物7a和7b的效果相当于0.1的吲哚美辛。结果表明，苯磺酰基对位上的吸电子取代基增加了活性。
Synthesis and anti-inflammatory activity of new 1-methyl-4-(4-X-benzenesulfonyl)pyrrolo[2,3-d] imidazole-5-carboxylates.
A series of 1-methyl-4-(4-X-arylsulfonyl)pyrrolo[2,3-d]imidazo-le-5-carboxylates were synthesized and tested as anti-inflammatory agents. Indomethacin was used as reference drug. Two of the synthesized compounds 7a and 7b had an effect equal to 0.1 of indomethacin. Our result showed that the electron-withdrawing substituents in the para position of the benzensulfonyl moiety increase activity.
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