{"title":"β-丙氨酸潜在拮抗剂β-氨基乙基酮的合成","authors":"Shu-Sing Cheng , Sigurdur Jonsson","doi":"10.1002/jps.3030490913","DOIUrl":null,"url":null,"abstract":"<div><p>The organocadmium reagent was adapted to the synthesis of alkyl β-aminoethyl ketones from β-alanine. Some aryl β-aminoethyl ketones were synthesized from β-alanine through the Friedel-Crafts reaction. These two series of β-aminoethyl ketones were proposed as potential antagonists of β-alanine in the metabolism of certain microorganisms. Both the alkyl and aryl β-aminoethyl ketones show antibacterial effect when tested against <em>S. aureus</em> and <em>E. coli in vitro</em>.</p></div>","PeriodicalId":100839,"journal":{"name":"Journal of the American Pharmaceutical Association (Scientific ed.)","volume":"49 9","pages":"Pages 611-613"},"PeriodicalIF":0.0000,"publicationDate":"1960-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/jps.3030490913","citationCount":"22","resultStr":"{\"title\":\"The Synthesis of β-Aminoethyl Ketones as Potential Antagonists of β-Alanine*\",\"authors\":\"Shu-Sing Cheng , Sigurdur Jonsson\",\"doi\":\"10.1002/jps.3030490913\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>The organocadmium reagent was adapted to the synthesis of alkyl β-aminoethyl ketones from β-alanine. Some aryl β-aminoethyl ketones were synthesized from β-alanine through the Friedel-Crafts reaction. These two series of β-aminoethyl ketones were proposed as potential antagonists of β-alanine in the metabolism of certain microorganisms. Both the alkyl and aryl β-aminoethyl ketones show antibacterial effect when tested against <em>S. aureus</em> and <em>E. coli in vitro</em>.</p></div>\",\"PeriodicalId\":100839,\"journal\":{\"name\":\"Journal of the American Pharmaceutical Association (Scientific ed.)\",\"volume\":\"49 9\",\"pages\":\"Pages 611-613\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1960-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1002/jps.3030490913\",\"citationCount\":\"22\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of the American Pharmaceutical Association (Scientific ed.)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0095955315363162\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of the American Pharmaceutical Association (Scientific ed.)","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0095955315363162","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
The Synthesis of β-Aminoethyl Ketones as Potential Antagonists of β-Alanine*
The organocadmium reagent was adapted to the synthesis of alkyl β-aminoethyl ketones from β-alanine. Some aryl β-aminoethyl ketones were synthesized from β-alanine through the Friedel-Crafts reaction. These two series of β-aminoethyl ketones were proposed as potential antagonists of β-alanine in the metabolism of certain microorganisms. Both the alkyl and aryl β-aminoethyl ketones show antibacterial effect when tested against S. aureus and E. coli in vitro.
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