Preparation of Tritium-Labeled Halothane (2-Bromo-2-chloro-1,1,1-trifluoroethane)*

Halothane was labeled with tritium (Wilzbach method) by exposure to 2.3 curies of tritium gas for fourteen days. The one hydrogen of the molecule was labeled and on purification gave a final specific activity of 2.9 mc. per Gm. In the preparation a considerable amount of ‘loose’ tritium and highly active impurities were separated and the purity of the final product following gas chromatographic purification was better than 99.95 per cent.