{"title":"各种巴比妥酸分布系数的相关性*","authors":"Donald J. Lamb, Loyd E. Harris","doi":"10.1002/jps.3030490906","DOIUrl":null,"url":null,"abstract":"<div><p>Evidence is provided to indicate that the distribution coefficients of various barbituric acids can be related to the number of carbon atoms and the Taft polar constants of the 5,5-substituents. This suggests that the hydrophilic portion of the molecule is affected not only by the size of the substituents but, also, by their polarity.</p></div>","PeriodicalId":100839,"journal":{"name":"Journal of the American Pharmaceutical Association (Scientific ed.)","volume":"49 9","pages":"Pages 583-585"},"PeriodicalIF":0.0000,"publicationDate":"1960-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/jps.3030490906","citationCount":"6","resultStr":"{\"title\":\"Correlation of the distribution coefficients of various barbituric acids*\",\"authors\":\"Donald J. Lamb, Loyd E. Harris\",\"doi\":\"10.1002/jps.3030490906\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Evidence is provided to indicate that the distribution coefficients of various barbituric acids can be related to the number of carbon atoms and the Taft polar constants of the 5,5-substituents. This suggests that the hydrophilic portion of the molecule is affected not only by the size of the substituents but, also, by their polarity.</p></div>\",\"PeriodicalId\":100839,\"journal\":{\"name\":\"Journal of the American Pharmaceutical Association (Scientific ed.)\",\"volume\":\"49 9\",\"pages\":\"Pages 583-585\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1960-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1002/jps.3030490906\",\"citationCount\":\"6\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of the American Pharmaceutical Association (Scientific ed.)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0095955315362971\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of the American Pharmaceutical Association (Scientific ed.)","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0095955315362971","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Correlation of the distribution coefficients of various barbituric acids*
Evidence is provided to indicate that the distribution coefficients of various barbituric acids can be related to the number of carbon atoms and the Taft polar constants of the 5,5-substituents. This suggests that the hydrophilic portion of the molecule is affected not only by the size of the substituents but, also, by their polarity.
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