急性呼吸窘迫综合征患者动态恶性通货膨胀的问题。

A Vieillard-Baron, F Jardin
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引用次数: 24

摘要

动态恶性充气是由于机械通气时弥漫性呼气流量限制损害了呼气而产生的。在支气管哮喘或慢性阻塞性肺疾病患者中,当需要机械通气时,这是一个严重的临床问题。但这种现象也可能使急性呼吸窘迫综合征(ARDS)患者的呼吸支持复杂化。过去有时会注意到ARDS患者存在弥漫性气流限制,但其后果直到最近才在一项动态研究中得到强调,该研究在呼吸支持期间使用床边记录流量/容积循环。最近,通过系统地记录延长的呼气,作者观察到大多数ARDS患者存在局部气流限制,这构成了呼吸支持下动态恶性通货膨胀的另一个潜在因素。在同一份报告中,现任作者强调了这种限制对压力/体积回路形状的影响。当提出增加呼吸支持以改善急性呼吸窘迫综合征患者的二氧化碳清除率时,动态恶性通货膨胀可能成为这种情况下的主要临床问题。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The issue of dynamic hyperinflation in acute respiratory distress syndrome patients.

Dynamic hyperinflation is produced by a diffuse expiratory flow limitation impairing exhalation under mechanical ventilation. It constitutes a serious clinical problem in patients exhibiting bronchial asthma or chronic obstructive pulmonary disease, when mechanical ventilation is required. But this phenomenon may also complicate respiratory support in acute respiratory distress syndrome (ARDS) patients. The presence of diffuse airflow limitation in ARDS patients has sometimes been noticed in the past, but its consequences have only recently been emphasised in a dynamic study, using bedside recording of flow/volume loops during respiratory support. More recently, by recording systematically a prolonged expiration, the current authors have observed a localised airflow limitation in a majority of ARDS patients, constituting another potential factor of dynamic hyperinflation under respiratory support. In the same report, the current authors' have emphasised the impact of this limitation on the shape of the pressure/volume loop. At a time when increasing respiratory support is proposed to improve carbon dioxide clearance in acute respiratory distress syndrome submitted to protective ventilation, dynamic hyperinflation may become a major clinical problem in this setting.

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