H Kamiya, N Murata-Kamiya, N Karino, Y Ueno, A Matsuda, H Kasai
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Mutagenicity of 5-formyluracil in mammalian cells.
5-Formyluracil, a major oxidized form of thymine, was incorporated into a predetermined site of one of the leading and lagging template strands of a double-stranded vector, and the DNA replication efficiency and the mutation frequency of 5-formyluracil in simian COS-7 cells were investigated. 5-Formyluracil did not block DNA replication and was weakly mutagenic in simian cells. 5-Formyluracil primarily elicited base substitutions at the modified positions.
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