羟甲基膦酸α - dna的化学合成。

Nucleic acids symposium series Pub Date : 2000-01-01
Y Sato, G Tateno, T Wada, K Seio, M Sekine
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引用次数: 0

摘要

本文报道了利用h -膦酸盐法合成羟甲基膦酸α - dna及其相关化合物。这些修饰的α - dna旨在通过引入更亲水的羟甲基膦酸功能来改善众所周知的甲基膦酸α - dna固有的低溶解度。研究了羟甲基膦酸α - dna的杂交能力。我们还报道了一种利用C1'-外映反应合成-胸腺嘧啶的新策略。将详细描述各种5'-和3'-羟基保护基团(如氨基甲酰基)对β -> α转化的邻近效应。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Chemical synthesis of hydroxymethylphosphonate alpha-DNA.

In this paper, we report the synthesis of hydroxymethylphosphonate alpha-DNAs and related compounds by use of the H-phosphonate method. These modified alpha-DNAs were designed to improve the inherent poor solubility of well-known methylphosphonate alpha-DNAs by introduction of a more hydrophilic hydroxymethylphosphonate function. The hybridization ability of hydroxymethylphosphonate alpha-DNAs was studied. We also report a novel strategy for the synthesis of alpha-thymidine by use of C1'-epimerization. The details of the neighboring effect of various 5'- and 3'-hydroxyl protective groups such as carbamoyl groups on the beta-->alpha conversion will be described.

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