碳环核苷的合成及其对SAH水解酶的抑制作用。

Nucleic acids symposium series Pub Date : 2000-01-01 DOI:10.1093/nass/44.1.111

Y Kitade, A Kozaki, T Miwa, M Nakanishi, C Yatome

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引用次数: 3

摘要

细胞酶s -腺苷- l-同型半胱氨酸(SAH)水解酶已成为抗病毒药物分子设计的靶酶。近年来，SAH水解酶被认为是疟疾寄生虫化疗的一个有吸引力的靶点。我们报道了几种碳环嘌呤核苷的合成及其对人和疟疾重组SAH水解酶的抑制活性。

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Synthesis of carbocyclic nucleosides and their SAH hydrolase inhibitory activities.

The cellular enzyme S-adenosyl-L-homocysteine (SAH) hydrolase has emerged as a target enzyme for the molecular design of anti-viral agents. Recently, SAH hydrolase has been considered as an attractive target in parasite chemotherapy for malaria. We report synthesis of several carbocyclic purine nucleosides and their inhibitory activities against human and malaria recombinant SAH hydrolases.

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Nucleic acids symposium series

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