具有咪唑啉环或四氢嘧啶环的DAPI(4′,6-二氨基-2-苯基吲哚)类似物的DNA结合特性:凹槽结合和插层。

Y Kubota, K Kubota, S Tani
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引用次数: 21

摘要

已经合成了含有咪唑啉环或四氢嘧啶环的DAPI类似物来研究DNA的结合特性。光谱(吸收、CD、流动二色性和荧光)和粘度测量表明,DAPI类似物通过嵌入和凹槽结合与DNA相互作用。用质子核磁共振光谱对DAPI类似物与DNA低聚物配合物的溶液结构进行了表征。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
DNA binding properties of DAPI (4',6-diamidino-2-phenylindole) analogs having an imidazoline ring or a tetrahydropyrimidine ring: groove-binding and intercalation.

DAPI analogs containing an imidazoline ring or a tetrahydropyrimidine ring have been synthesized to study DNA binding properties. Spectroscopic (absorption, CD, flow dichroism and fluorescence) and viscosity measurements indicate that DAPI analogs interact with DNA both by intercalation and by groove binding. The solution structures of complexes between DAPI analog and DNA oligomers have been characterized by proton NMR spectroscopy.

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