垂体发育中的成对抑制/激活。

Lorin E Olson, Jeremy S Dasen, Bong Gun Ju, Jessica Tollkuhn, Michael G Rosenfeld
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引用次数: 22

摘要

垂体发育受信号控制,这些信号引导转录因子的特定组合表达,这些转录因子决定了一系列的决定和分化事件。一类因子是类配对同域因子。其中两个已被研究的是抑制因子Hex1/Rpx和Pit-1的激活因子Prop-1,它们在垂体发育过程中发挥选择性作用。这些因素的相反作用提供了垂体器官发生的一个方面。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Paired-like repression/activation in pituitary development.

Pituitary gland development is controlled by signals that guide expression of specific combinations of transcription factors that dictate serial determination and differentiation events. One class of factors is paired-like homeodomain factors. Two that have been investigated are the repressor Hex1/Rpx and activator prophet of Pit-1 (Prop-1), which exert selective roles during pituitary development. The opposing actions of these factors provide one aspect of pituitary organogenesis.

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