初级保健中冠心病的患病率和管理:使用疾病登记的基于人群的横断面研究

Kevin Carroll, Azeem Majeed, Caroline Firth, Jeremy Gray
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引用次数: 106

摘要

背景:冠心病患者是进一步发生冠状动脉事件的高危人群。因此,国家冠心病服务框架战略的主要优先事项之一是识别和治疗已存在冠心病的患者。我们的目的是确定大型初级保健人群中已确诊冠心病的患病率,并将这些患者的危险因素管理与国家服务框架中给出的标准进行比较。方法:以人群为基础的横断面研究使用从初级保健收集的数据进行。伦敦西南部四个初级保健组的63名全科医生(总名单大小为378,021)参与了研究。数据收集仅限于44岁以上的103,613例患者。我们计算了年龄、性别和年龄标准化的患病率,以及男性和女性的年龄调整相对风险。结果:总共确定了6,778名冠心病患者(8%的男性和5%的44岁以上的女性)。30%(1204/3991)男性有心肌梗死史,22%(613/2787)女性有心肌梗死史(相对危险度1.57;1.37 - -1.81)。27%的男性(1068/3991)和11%的女性(312/2787)接受了冠状动脉血管重建术(2.02;1.73 - -2.35)。大多数患者被评估为高血压(89%(3538/3991)的男性;90%(2500/ 2787)的女性),但在许多患者中血压控制不良(26%(902/3538)的男性;27%(678/2500)的妇女)。最近,51%(2018/3991)的男性和44%(1218/2787)的女性测量了总胆固醇,44%(881/ 2018)的男性和59%(716/1218)的女性(0.74;0.69 - -0.79)。49%(1967/3991)的男性和38%(1064/2787)的女性(1.06;1.00 - -1.12)。65%(2586/3991)的男性和59%(1631/2787)的女性(1.08;1.03 - -1.14)。20%(181/913)的男性和15%(72/499)的有心肌梗死史的女性服用-受体阻滞剂(1.11;0.85 - -1.44)。结论:大多数冠心病患者在初级保健中接受阿司匹林治疗,但只有不到一半的患者接受他汀类药物或受体阻滞剂治疗。服用阿司匹林和他汀类药物的男性多于女性,尽管女性的胆固醇水平高于男性。男性也更有可能确诊并接受冠状动脉血管重建术。在改善冠心病的二级预防和解决初级保健中的性别不平等问题方面还有相当大的空间。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Prevalence and management of coronary heart disease in primary care: population-based cross-sectional study using a disease register.

Background: Patients with coronary heart disease are at high risk of further coronary events. Hence, one of the main priorities in the National Service Framework for Coronary Heart Disease strategy is the identification and treatment of patients with pre-existing coronary heart disease. We aimed to determine the prevalence of established coronary heart disease in a large primary care population and to compare the management of risk factors in these patients with the standards given in the National Service Framework.

Methods: A population-based cross-sectional study was carried out using data collected from primary care. Sixty-three general practices (total list size 378,021) in four primary care groups in SW London took part. Data collection was confined to 103,613 patients over 44 years of age. We calculated age- and sex-specific and age-standardized prevalence rates, and age-adjusted relative risks for men and women.

Results: A total of 6,778 patients with coronary heart disease were identified (8 per cent of men and 5 per cent of women over 44 years of age). There was a history of myocardial infarction in 30 per cent (1204/3991) of men and 22 per cent (613/2787) of women (relative risk 1.57; 1.37-1.81). Coronary revascularization procedures had been performed in 27 per cent (1068/3991) of men and 11 per cent (312/2787) of women (2.02; 1.73-2.35). Most patients had been assessed for hypertension (89 per cent (3538/3991) of men; 90 per cent (2500/ 2787) of women), but in many patients blood pressure was poorly controlled (26 per cent (902/3538) of men; 27 per cent (678/2500) of women). Total cholesterol had been recently measured in 51 per cent (2018/3991) of men and 44 per cent (1218/2787) of women and was elevated in 44 per cent (881/ 2018) of men and 59 per cent (716/1218) of women (0.74; 0.69-0.79). Statins were prescribed to 49 per cent (1967/3991) of men and 38 per cent (1064/2787) of women (1.06; 1.00-1.12). Aspirin was prescribed to 65 per cent (2586/3991) of men and 59 per cent (1631/2787) of women (1.08; 1.03-1.14). Beta-blockers were prescribed to 20 per cent (181/913) of men and 15 per cent (72/499) of women with a history of myocardial infarction (1.11; 0.85-1.44).

Conclusions: Most patients with coronary heart disease in primary care were being treated with aspirin but less than half with statins or beta-blockers. More men than women were treated with aspirin and statins, even though women had higher cholesterol levels than men. Men were also more likely to have a confirmed diagnosis and to have undergone a coronary revascularization procedure. There is considerable scope for improving the secondary prevention of coronary heart disease and addressing gender inequalities in primary care.

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