{"title":"布卢姆氏综合症解旋酶:阻止癌症。","authors":"Payam Mohaghegh, Ian D Hickson","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Bloom's syndrome, a very rare inherited disorder, predisposes its sufferers to the full range of cancers that afflict humanity. This predisposition is rooted in just one defective gene on chromosome 15. It encodes the BLM helicase - an enzyme that ordinarily protects against DNA damage arising during replication.</p>","PeriodicalId":39845,"journal":{"name":"Biologist","volume":"50 1","pages":"29-33"},"PeriodicalIF":0.0000,"publicationDate":"2003-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The Bloom's syndrome helicase: keeping cancer at bay.\",\"authors\":\"Payam Mohaghegh, Ian D Hickson\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Bloom's syndrome, a very rare inherited disorder, predisposes its sufferers to the full range of cancers that afflict humanity. This predisposition is rooted in just one defective gene on chromosome 15. It encodes the BLM helicase - an enzyme that ordinarily protects against DNA damage arising during replication.</p>\",\"PeriodicalId\":39845,\"journal\":{\"name\":\"Biologist\",\"volume\":\"50 1\",\"pages\":\"29-33\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2003-02-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Biologist\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"Agricultural and Biological Sciences\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biologist","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Agricultural and Biological Sciences","Score":null,"Total":0}
The Bloom's syndrome helicase: keeping cancer at bay.
Bloom's syndrome, a very rare inherited disorder, predisposes its sufferers to the full range of cancers that afflict humanity. This predisposition is rooted in just one defective gene on chromosome 15. It encodes the BLM helicase - an enzyme that ordinarily protects against DNA damage arising during replication.