非格昔汀对外周血干细胞稳态动员的影响。

Shinichiro Hashimoto, Michihiro Itoh, Miki Nishimura, Takayoshi Asai
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引用次数: 9

摘要

为了获得更好的(最佳)外周血干细胞(PBSC)采集计划,我们比较了非格司汀(8微克/千克/天与16微克/千克/天)剂量对外周血干细胞稳态动员的影响。非格昔汀8微克/千克/天的剂量与16微克/千克/天的剂量效果无显著差异。在接受8微克/千克/天的患者组中,3名没有长期联合化疗史的患者收获了超过3 × 10(6)/千克供体体重的CD34+细胞。采用8 μ g/kg非格司汀动员24例健康供体的同种异体外周血母细胞。所有健康的供者捐献了足够数量的PBSCs (CD34+细胞超过4 × 10(6)/kg受体体重),并且对这种动员具有良好的耐受性,无严重并发症。在用健康供体动员PBSC时,在大多数情况下,从第4天到第6天,CD34+细胞的最大产量出现在第5天。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effect of filgrastim administration for steady-state mobilization of peripheral blood stem cells.

To obtain a better (optimal) schedule of peripheral blood stem cell (PBSC) collection by steady-state granulocyte colony-stimulating factor administrations for autologous or allogeneic transplantations, we compared the effect of doses of filgrastim (8 microg/kg/day versus 16 microg/kg/day) for the steady-state mobilization of PBSCs. The effects of a filgrastim dose of 8 microg/kg/day were not significantly different from those of a dose of 16 microg/kg/day. In the group of patients receiving 8 microg/kg/day, the CD34+ cells over 3 x 10(6)/kg donor body weight were harvested in 3 patients who did not have a long history of receiving combination chemotherapy. The administration of 8 microg/kg filgrastim was adopted also for allogeneic PBSC mobilization for 24 healthy donors. All healthy donors donated an adequate number of PBSCs (CD34+ cells over 4 x 10(6)/kg of recipient body weight) and tolerated this mobilization well with no serious complications. In PBSC mobilization with healthy donors, the maximal yields of CD34+ cells from Day 4 to Day 6 were seen on the fifth day in most cases.

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