Laura Martínez de Villarreal, Jesús Z Villarreal Pérez, Patricia Arredondo Vázquez, Ricardo Hernández Herrera, Ma Del Roble Velazco Campos, Roberto Ambriz López, José Luis Herrera Ramírez, Jesús Manuel Yañez Sánchez, Juan José Morales Villarreal, Manuel Treviño Garza, Adriana Limón, Abel Guzmán López, Mario Bárcenas, Juan Ramón Cepeda García, Andrés Sánchez Domínguez, Rogelio Hernández Nuñez, Jorge Luis García Ayala, Jorge Garza Martínez, Mario Tijerina González, Carlos García Alvarez, Roberto Negrete Castro
{"title":"叶酸运动后神经管缺陷病例在新evo León, msamuxico的下降。","authors":"Laura Martínez de Villarreal, Jesús Z Villarreal Pérez, Patricia Arredondo Vázquez, Ricardo Hernández Herrera, Ma Del Roble Velazco Campos, Roberto Ambriz López, José Luis Herrera Ramírez, Jesús Manuel Yañez Sánchez, Juan José Morales Villarreal, Manuel Treviño Garza, Adriana Limón, Abel Guzmán López, Mario Bárcenas, Juan Ramón Cepeda García, Andrés Sánchez Domínguez, Rogelio Hernández Nuñez, Jorge Luis García Ayala, Jorge Garza Martínez, Mario Tijerina González, Carlos García Alvarez, Roberto Negrete Castro","doi":"10.1002/tera.10094","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Nuevo León is a state in northeastern Mexico, near the border of Texas. Mean mortality rate from 1996-98 due to anencephaly cases was 0.6/1,000. In 1999 a surveillance program for the registry and prevention of neural tube defects (NTD) cases was initiated.</p><p><strong>Methods: </strong>Cases were obtained from hospitals and OB-GYN clinics by immediate notification, death certificates, or fetal death registries. Only isolated cases of NTD were included. In August 1999 a folic acid campaign was initiated with the free distribution of the vitamin to low-income women with a recommendation to take a 5.0-mg pill once a week. Number of cases and rates from 1999 to 2001 were compared (chi(2) test).</p><p><strong>Results: </strong>After 2 years there has been a significant reduction in the number of cases and rates. In 1999 there were 95 NTD cases and in the years 2000 and 2001 there were only 59 and 55 respectively (P < 0.001). NTD rate decreased from 1.04/1,000 in 1999 to 0.58/1,000 in 2001. Anencephaly and spina bifida rates decreased from 0.55/1,000 to 0.29/1,000 and from 0.47/1,000 to 0.22/1,000 respectively, from 1999-2001. Decrease of female cases was higher than male cases for both phenotypes.</p><p><strong>Conclusion: </strong>After 2 years there was a 50% decrease in the incidence of anencephaly and spina bifida cases with a significant reduction of infant mortality and disability. These results encourage us to propose the use of a single tablet of 5.0-mg of folic acid per week as an alternative to supplementation on a daily basis.</p>","PeriodicalId":22211,"journal":{"name":"Teratology","volume":"66 5","pages":"249-56"},"PeriodicalIF":0.0000,"publicationDate":"2002-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/tera.10094","citationCount":"60","resultStr":"{\"title\":\"Decline of neural tube defects cases after a folic acid campaign in Nuevo León, México.\",\"authors\":\"Laura Martínez de Villarreal, Jesús Z Villarreal Pérez, Patricia Arredondo Vázquez, Ricardo Hernández Herrera, Ma Del Roble Velazco Campos, Roberto Ambriz López, José Luis Herrera Ramírez, Jesús Manuel Yañez Sánchez, Juan José Morales Villarreal, Manuel Treviño Garza, Adriana Limón, Abel Guzmán López, Mario Bárcenas, Juan Ramón Cepeda García, Andrés Sánchez Domínguez, Rogelio Hernández Nuñez, Jorge Luis García Ayala, Jorge Garza Martínez, Mario Tijerina González, Carlos García Alvarez, Roberto Negrete Castro\",\"doi\":\"10.1002/tera.10094\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Nuevo León is a state in northeastern Mexico, near the border of Texas. Mean mortality rate from 1996-98 due to anencephaly cases was 0.6/1,000. In 1999 a surveillance program for the registry and prevention of neural tube defects (NTD) cases was initiated.</p><p><strong>Methods: </strong>Cases were obtained from hospitals and OB-GYN clinics by immediate notification, death certificates, or fetal death registries. Only isolated cases of NTD were included. In August 1999 a folic acid campaign was initiated with the free distribution of the vitamin to low-income women with a recommendation to take a 5.0-mg pill once a week. Number of cases and rates from 1999 to 2001 were compared (chi(2) test).</p><p><strong>Results: </strong>After 2 years there has been a significant reduction in the number of cases and rates. In 1999 there were 95 NTD cases and in the years 2000 and 2001 there were only 59 and 55 respectively (P < 0.001). NTD rate decreased from 1.04/1,000 in 1999 to 0.58/1,000 in 2001. Anencephaly and spina bifida rates decreased from 0.55/1,000 to 0.29/1,000 and from 0.47/1,000 to 0.22/1,000 respectively, from 1999-2001. Decrease of female cases was higher than male cases for both phenotypes.</p><p><strong>Conclusion: </strong>After 2 years there was a 50% decrease in the incidence of anencephaly and spina bifida cases with a significant reduction of infant mortality and disability. These results encourage us to propose the use of a single tablet of 5.0-mg of folic acid per week as an alternative to supplementation on a daily basis.</p>\",\"PeriodicalId\":22211,\"journal\":{\"name\":\"Teratology\",\"volume\":\"66 5\",\"pages\":\"249-56\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2002-11-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1002/tera.10094\",\"citationCount\":\"60\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Teratology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1002/tera.10094\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Teratology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1002/tera.10094","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Decline of neural tube defects cases after a folic acid campaign in Nuevo León, México.
Background: Nuevo León is a state in northeastern Mexico, near the border of Texas. Mean mortality rate from 1996-98 due to anencephaly cases was 0.6/1,000. In 1999 a surveillance program for the registry and prevention of neural tube defects (NTD) cases was initiated.
Methods: Cases were obtained from hospitals and OB-GYN clinics by immediate notification, death certificates, or fetal death registries. Only isolated cases of NTD were included. In August 1999 a folic acid campaign was initiated with the free distribution of the vitamin to low-income women with a recommendation to take a 5.0-mg pill once a week. Number of cases and rates from 1999 to 2001 were compared (chi(2) test).
Results: After 2 years there has been a significant reduction in the number of cases and rates. In 1999 there were 95 NTD cases and in the years 2000 and 2001 there were only 59 and 55 respectively (P < 0.001). NTD rate decreased from 1.04/1,000 in 1999 to 0.58/1,000 in 2001. Anencephaly and spina bifida rates decreased from 0.55/1,000 to 0.29/1,000 and from 0.47/1,000 to 0.22/1,000 respectively, from 1999-2001. Decrease of female cases was higher than male cases for both phenotypes.
Conclusion: After 2 years there was a 50% decrease in the incidence of anencephaly and spina bifida cases with a significant reduction of infant mortality and disability. These results encourage us to propose the use of a single tablet of 5.0-mg of folic acid per week as an alternative to supplementation on a daily basis.
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