凝血、纤溶和血管生成:来自基因敲除小鼠的新见解。

Sergey V Brodsky
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引用次数: 15

摘要

血管生成在一系列广泛的生理和病理过程中起着关键作用。两个主要的系统——凝血和纤溶——维持止血,最近被认为与血管生成有关。产生凝血和纤溶酶原系统成分缺乏的小鼠提供了一个非凡的机会来定义这些系统在体内的作用,并阐明参与血管生成的分子机制。似乎凝血系统的几个因子,如组织因子、因子V和凝血酶受体,在胚胎血管形成中起重要作用,最有可能在原始血管壁的形成中起重要作用。此外,纤溶酶原系统似乎在成人血管生成中发挥重要作用,调节内皮细胞和平滑肌细胞的迁移,细胞外基质的降解和金属蛋白酶系统的活性。这些新发现为未来的治疗策略提供了一种可能性,可以在组织血管化异常的病理突出的不同病理过程中特异性地控制血管生成。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Coagulation, fibrinolysis and angiogenesis: new insights from knockout mice.

Angiogenesis plays a key role in a broad array of physiologic and pathologic processes. Two major systems--coagulation and fibrinolysis--maintaining hemostasis, have recently been implicated in angiogenesis. Generation of mice deficient in components of coagulation and plasminogen systems has provided an extraordinary opportunity to define the role of each of these systems in vivo and to elucidate molecular mechanisms involved in angiogenesis. It appears that several factors of the coagulation system, such as the tissue factor, the factor V and the thrombin receptor, play an important role in embryonic vessel formation, most probably in the formation of the primitive vascular wall. In addition, the plasminogen system appears to play a significant role in angiogenesis in adulthood, regulating the migration of endothelial and smooth muscle cells, the degradation of the extracellular matrix and activity of the metalloproteinase system. These new revelations open a possibility for future therapeutic strategies to specifically control angiogenesis in different pathological processes where abnormalities of tissue vascularization are pathogenetically prominent.

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