[烟酰胺腺嘌呤二核苷酸对3-乙酰吡啶给药大鼠脑5 -羟色胺能介质系统的影响]。

Voprosy meditsinskoi khimii Pub Date : 2002-05-01

T M Kuchmerovskaia, G V Chichkovskaia, L V Pakirbaeva, A A Khalmuradov

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引用次数: 0

摘要

研究了3-乙酰吡啶(抗维生素B3)对大鼠脑血清素能和NAD受体系统的影响。大鼠注射3-乙酰吡啶后，脑内NAD和5 -羟色胺含量降低，[U-14C]NAD与突触膜结合、神经末梢对5 -羟色胺的摄取以及对NAD的敏感性发生变化(10-5 M)，烟酰胺预处理恢复NAD的调节作用。

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[Effect of nicotinamide adenine dinucleotide on the serotoninergic mediator system in the rat brain during 3-acetylpyridine administration].

The effect of administration of 3-acetylpyridine (antivitamin B3), on rat brain serotoninergic and NAD receptor systems was investigated. The injection of 3-acetylpyridine to rats caused a decrease of NAD and serotonin content in the brain and changes in [U-14C]NAD binding to synaptic membranes, serotonin uptake by nerve endings, as well as sensitivity of this process to NAD (10-5 M). Pretreatment of animals with nicotinamide restored modulating effect of NAD.

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Voprosy meditsinskoi khimii

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