国家毒理学规划关于草甘膦在F344/N大鼠和B6C3F1小鼠中给药的毒性研究的技术报告(CAS No. 1071-83-6)。

Toxicity report series Pub Date : 1992-07-01
Po Chan, Joel Mahler
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引用次数: 0

摘要

草甘膦是一种用于非选择性杂草控制的系统性、广谱、羽化后除草剂。之所以选择它进行研究,是因为它的广泛使用、人类接触的可能性,以及缺乏关于全面毒性或致癌性评估的已发表报告。对草甘膦进行了化学处理、13周毒性和致突变性研究。在处置研究中,雄性F344/N大鼠口服14c -草甘膦(5.6或56 mg/kg)。收集血液、尿液、粪便和组织样本并分析放射性。在草甘膦给药后72小时内,20-30%的放射性通过尿液排出,70-80%通过粪便排出,约1%的放射性残留在组织中。口服、静脉注射和腹腔注射草甘膦后的研究表明,尿液放射性代表草甘膦的吸收量,粪便放射性代表未从胃肠道吸收的量。在为期13周的毒性研究中,每组10只雄性和雌性F344/N大鼠和B6C3F1小鼠分别被给予0、3125、6250、12500、25000或50000 ppm的草甘膦饲料。草甘膦引起大鼠血清胆汁酸、碱性磷酸酶和丙氨酸转氨酶活性升高,提示对肝胆系统有轻微毒性。未对小鼠进行临床病理测量。大鼠、小鼠肝脏未见组织病理学损伤。没有证据表明对大鼠或小鼠的生殖系统有不良影响。大鼠腮腺和下颌下唾液腺及小鼠腮腺唾液腺细胞质发生改变。草甘膦对唾液腺的影响是通过肾上腺素能机制介导的,可被肾上腺素能拮抗剂丙酚阻断。草甘膦对沙门氏菌无诱变作用,对小鼠无微核作用。小鼠饮食中唾液腺病变的未观察到的不良反应水平(NOAEL)为3125 ppm。从大鼠研究中无法确定NOAEL。草甘膦,技术级;甘氨酸,N - (phosphonomethyl);N-phosphono-methyl甘氨酸;N - (phosphonomethyl)甘氨酸;我的0573;我的2139。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
NTP technical report on the toxicity studies of Glyphosate (CAS No. 1071-83-6) Administered In Dosed Feed To F344/N Rats And B6C3F1 Mice.

Glyphosate is a systemic, broad-spectrum, post-emergence herbicide used for non-selective weed control. It was selected for study because of its widespread use, potential for human exposure, and the lack of published reports concerning comprehensive toxicity or carcinogenicity evaluations. Chemical disposition, 13-week toxicity, and mutagenicity studies of glyphosate were conducted. In disposition studies, male F344/N rats were administered an oral dose (5.6 or 56 mg/kg) of 14C-glyphosate. Blood, urine, fecal, and tissue samples were collected and analyzed for radioactivity. Within 72 hours after glyphosate dosing, 20-30% of the administered radioactivity was eliminated via urine, 70-80% via feces, and about 1% of the radioactivity remained in the tissues. Studies following oral, intravenous, and intraperitoneal administration of glyphosate indicated that the urinary radioactivity represented the amount of glyphosate absorbed and that the fecal radioactivity represented the amount unabsorbed from the gastrointestinal tract. In the 13-week toxicity studies, groups of 10 male and female F344/N rats and B6C3F1 mice were administered glyphosate in feed at 0, 3125, 6250, 12500, 25000, or 50000 ppm. Glyphosate administration induced increases in serum bile acids, alkaline phosphatase, and alanine aminotransferase activities in rats, suggesting mild toxicity to the hepatobiliary system. Clinical pathology measurements were not performed with mice. No histopathologic lesions were observed in the livers of rats or mice. There was no evidence of adverse effects on the reproductive system of rats or mice. Cytoplasmic alteration was observed in the parotid and submandibular salivary glands of rats and parotid salivary glands in mice. The salivary gland effects of glyphosate were demonstrated to be mediated through an adrenergic mechanism which could be blocked by the adrenergic antagonist, propanolol. Glyphosate was not mutagenic in Salmonella, and did not induce micronuclei in mice. The no-observed-adverse-effect level (NOAEL) for the salivary gland lesions was 3125 ppm in the diet for mice. A NOAEL could not be determined from the rat study. Synonyms: Glyphosate, technical grade; Glycine, N-(phosphonomethyl); N-phosphono-methyl glycine; N-(phosphonomethyl)glycine; MON 0573; MON 2139.

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