动态胶束电动力学色谱法测定恶西泮的对映异构势垒——实验与chromwin99模拟的比较。

Enantiomer Pub Date : 2000-01-01

G Schoetz, O Trapp, V Schurig

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引用次数: 0

摘要

以胆酸钠为手性表面活性剂，用动态胶束电色谱法研究了恶西泮的ph依赖性和温控对映异构化。利用新程序chromwin99模拟了具有高原地层特征的实验转换剖面。峰形分析得到了奥西泮在5 ~ 25℃间对映异构化的速率常数和动力学活化参数。

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Determination of the enantiomerization barrier of oxazepam by dynamic micellar electrokinetic chromatography--comparison of experiment and simulation with ChromWin 99.

The pH-dependent and temperature-controlled enantiomerization of oxazepam has been studied by dynamic micellar electrokinetic chromatography in an aqueous buffer system with sodium cholate as the chiral surfactant. Experimental interconversion profiles featuring plateau formation were simulated by the new program ChromWin 99. Peak form analysis yielded rate constants and kinetic activation parameters of the enantiomerization of oxazepam between 5 degrees C and 25 degrees C.

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