胰头癌和壶腹周围癌预后研究的汇总:三重p研究。3p学习小组。

C B Terwee, E J Nieveen Van Dijkum, D J Gouma, K E Bakkevold, J H Klinkenbijl, T P Wade, B A van Wagensveld, A Wong, J H van der Meulen
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引用次数: 43

摘要

目的:为不能切除的胰腺癌患者开发一种预后工具,以区分诊断后3 - 9个月生存率低或高的患者。设计:汇总来自5项研究的个体患者数据。建立了一个具有时间相关协变量的多变量比例风险模型,包括年龄、性别和转移灶。一个扩展模型被开发在一个子集的患者,包括体重减轻,疼痛和黄疸诊断。环境:多中心研究,荷兰、挪威、美国、英国和加拿大。研究对象:1020例不能切除的胰腺癌患者。主要观察指标:预测预后。结果:诊断时出现转移、疼痛或体重减轻的患者预后明显差于其他患者。老年男性的预后比年轻男性差,而老年女性的预后比年轻女性好。黄疸患者预后较好。研究间的生存差异被纳入预后评分表。结论:预后评分表可用于选择生存期望相对较低的内镜下姑息患者和手术姑息期望相对较高的患者。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Pooling of prognostic studies in cancer of the pancreatic head and periampullary region: the Triple-P study. Triple-P study group.

Objective: Development of a prognostic tool for patients with unresectable pancreatic cancer to distinguish between with low or high probabilities of survival 3 to 9 months after diagnosis.

Design: Data about individual patients from five studies were pooled. A multivariate proportional hazards model with time-dependent covariates was developed, including age, sex, and metastases. An extended model was developed on a subset of patients, including weight loss, pain, and jaundice at diagnosis.

Setting: Multicentre study, The Netherlands, Norway, USA, UK, and Canada.

Subjects: 1020 patients with unresectable pancreatic cancer.

Main outcome measures: Prediction of prognosis.

Results: Patients with metastases, pain, or weight loss at diagnosis had a significantly poorer prognosis than the others. Older men had a worse prognosis than younger men, while older women had a better prognosis than younger ones. Patients with jaundice had a relatively good prognosis. Differences in survival among the studies were incorporated in a prognostic score chart.

Conclusion: The prognostic score chart can be used to select patients with relatively low expectation of survival for endoscopic palliation, and patients with relatively high expectation for surgical palliation.

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