C B Terwee, E J Nieveen Van Dijkum, D J Gouma, K E Bakkevold, J H Klinkenbijl, T P Wade, B A van Wagensveld, A Wong, J H van der Meulen
{"title":"胰头癌和壶腹周围癌预后研究的汇总:三重p研究。3p学习小组。","authors":"C B Terwee, E J Nieveen Van Dijkum, D J Gouma, K E Bakkevold, J H Klinkenbijl, T P Wade, B A van Wagensveld, A Wong, J H van der Meulen","doi":"10.1080/110241500750008466","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>Development of a prognostic tool for patients with unresectable pancreatic cancer to distinguish between with low or high probabilities of survival 3 to 9 months after diagnosis.</p><p><strong>Design: </strong>Data about individual patients from five studies were pooled. A multivariate proportional hazards model with time-dependent covariates was developed, including age, sex, and metastases. An extended model was developed on a subset of patients, including weight loss, pain, and jaundice at diagnosis.</p><p><strong>Setting: </strong>Multicentre study, The Netherlands, Norway, USA, UK, and Canada.</p><p><strong>Subjects: </strong>1020 patients with unresectable pancreatic cancer.</p><p><strong>Main outcome measures: </strong>Prediction of prognosis.</p><p><strong>Results: </strong>Patients with metastases, pain, or weight loss at diagnosis had a significantly poorer prognosis than the others. Older men had a worse prognosis than younger men, while older women had a better prognosis than younger ones. Patients with jaundice had a relatively good prognosis. Differences in survival among the studies were incorporated in a prognostic score chart.</p><p><strong>Conclusion: </strong>The prognostic score chart can be used to select patients with relatively low expectation of survival for endoscopic palliation, and patients with relatively high expectation for surgical palliation.</p>","PeriodicalId":22411,"journal":{"name":"The European journal of surgery = Acta chirurgica","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2000-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/110241500750008466","citationCount":"43","resultStr":"{\"title\":\"Pooling of prognostic studies in cancer of the pancreatic head and periampullary region: the Triple-P study. Triple-P study group.\",\"authors\":\"C B Terwee, E J Nieveen Van Dijkum, D J Gouma, K E Bakkevold, J H Klinkenbijl, T P Wade, B A van Wagensveld, A Wong, J H van der Meulen\",\"doi\":\"10.1080/110241500750008466\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>Development of a prognostic tool for patients with unresectable pancreatic cancer to distinguish between with low or high probabilities of survival 3 to 9 months after diagnosis.</p><p><strong>Design: </strong>Data about individual patients from five studies were pooled. A multivariate proportional hazards model with time-dependent covariates was developed, including age, sex, and metastases. An extended model was developed on a subset of patients, including weight loss, pain, and jaundice at diagnosis.</p><p><strong>Setting: </strong>Multicentre study, The Netherlands, Norway, USA, UK, and Canada.</p><p><strong>Subjects: </strong>1020 patients with unresectable pancreatic cancer.</p><p><strong>Main outcome measures: </strong>Prediction of prognosis.</p><p><strong>Results: </strong>Patients with metastases, pain, or weight loss at diagnosis had a significantly poorer prognosis than the others. Older men had a worse prognosis than younger men, while older women had a better prognosis than younger ones. Patients with jaundice had a relatively good prognosis. Differences in survival among the studies were incorporated in a prognostic score chart.</p><p><strong>Conclusion: </strong>The prognostic score chart can be used to select patients with relatively low expectation of survival for endoscopic palliation, and patients with relatively high expectation for surgical palliation.</p>\",\"PeriodicalId\":22411,\"journal\":{\"name\":\"The European journal of surgery = Acta chirurgica\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2000-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1080/110241500750008466\",\"citationCount\":\"43\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The European journal of surgery = Acta chirurgica\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1080/110241500750008466\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The European journal of surgery = Acta chirurgica","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1080/110241500750008466","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Pooling of prognostic studies in cancer of the pancreatic head and periampullary region: the Triple-P study. Triple-P study group.
Objective: Development of a prognostic tool for patients with unresectable pancreatic cancer to distinguish between with low or high probabilities of survival 3 to 9 months after diagnosis.
Design: Data about individual patients from five studies were pooled. A multivariate proportional hazards model with time-dependent covariates was developed, including age, sex, and metastases. An extended model was developed on a subset of patients, including weight loss, pain, and jaundice at diagnosis.
Setting: Multicentre study, The Netherlands, Norway, USA, UK, and Canada.
Subjects: 1020 patients with unresectable pancreatic cancer.
Main outcome measures: Prediction of prognosis.
Results: Patients with metastases, pain, or weight loss at diagnosis had a significantly poorer prognosis than the others. Older men had a worse prognosis than younger men, while older women had a better prognosis than younger ones. Patients with jaundice had a relatively good prognosis. Differences in survival among the studies were incorporated in a prognostic score chart.
Conclusion: The prognostic score chart can be used to select patients with relatively low expectation of survival for endoscopic palliation, and patients with relatively high expectation for surgical palliation.