肥胖患者脂肪组织血管紧张素原基因表达的研究。

G Giacchetti, E Faloia, C Sardu, M A Camilloni, B Mariniello, C Gatti, G G Garrapa, M Guerrieri, F Mantero
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引用次数: 110

摘要

近年来,有关肾素-血管紧张素系统(RAS)的组成部分血管紧张素原(AGT)、血管紧张素转换酶和血管紧张素II受体的基因在脂肪组织中得到了描述。在动物模型中,脂肪组织中的血管紧张素原与肥胖相关的代谢改变和高血压的发病机制有关。我们的研究目的是评估AGT基因在肥胖患者和瘦受试者内脏和皮下脂肪组织中的表达。采用特异引物逆转录聚合酶链反应(RT-PCR)检测AGT mRNA水平。肥胖患者的AGT mRNA表达水平不同。内脏脂肪组织明显高于皮下脂肪组织。内脏脂肪组织中AGT表达与BMI呈显著正相关。这些数据提示血管紧张素原可能是脂肪分布的决定因素,并可能参与中枢性肥胖的多代谢综合征。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Gene expression of angiotensinogen in adipose tissue of obese patients.

Recently, the genes of components of the renin-angiotensin system (RAS), namely angiotensinogen (AGT), angiotensin converting enzyme and angiotensin II receptor have been described in adipose tissue. In animal models the angiotensinogen in adipose tissue has been implicated in the pathogenesis of metabolic alterations and hypertension associated with obesity. The aim of our study was to evaluate the AGT gene expression both in visceral and subcutaneous adipose tissue in obese patients and lean subjects. AGT mRNA levels were measured by reverse transcriptase polymerase chain reaction (RT-PCR) using specific primers. AGT mRNA was expressed at variable levels in obese patients. It was significantly greater in visceral than in subcutaneous adipose tissue. Positive and significant correlation was found between the expression of AGT in visceral adipose tissue and BMI. These data suggest that angiotensinogen may be determinant of fat distribution and may be involved in the plurimetabolic syndrome of central obesity.

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