汉森氏神经炎的内科和外科联合治疗的随机对照试验

Acta leprologica Pub Date : 1999-01-01
P Boucher, J Millan, M Parent, J P Moulia-Pela
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引用次数: 0

摘要

本研究的目的是比较麻疯病神经炎的单独药物治疗和内外科治疗的结果。患者随访2年,定期进行神经学评估。统计学研究采用Tukey检验。对31例麻风病患者的93条神经(尺神经、正中神经、腓总神经和胫后神经)缺损时间小于6个月进行了研究。所有患者均接受类固醇治疗,但其中一些患者进行了神经手术减压。两组患者的敏感和运动缺陷均有改善。两组在受累神经、缺陷持续时间、麻风形式、抗菌治疗方式等方面差异无统计学意义。然而,内科手术治疗在疼痛和主要但不完全的神经受累方面有明显更好的效果。本研究纳入的神经数量有限,因此,进行其他随机分析以更好地确定麻风病神经炎手术减压的适应症将是有用的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[Randomized controlled trial of medical and medico-surgical treatment of Hansen's neuritis].

The aim of the study was to compare the results of the medical treatment alone and of the medico-surgical treatment on leprous neuritis. The patients were followed-up during 2 years, with regular neurological evaluations. The statistical study was performed using the Tukey test. Ninety-three nerves (ulnar, median, common peroneal and posterior tibial) with a deficit of less than 6 months duration have been studied in 31 leprosy patients. All the patients were treated by steroids but in some of them a nerve surgical decompression was performed. An improvement of the sensitive and motor deficit was observed in both groups. No significant statistical differences appeared between the 2 groups according to the nerve involved, the duration of the deficit, the form of leprosy and the type of antibacillary treatment. However, the medico-surgical treatment had a significant better result on pain and on major but incomplete nervous involvement. This study included a limited number of nerves, thus, it would be useful to perform others randomized assays to better define the indications of surgical decompression in the management of leprous neuritis.

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