The Development of Trypanosoma cruzi in Triatominae

Trypanosoma cruzi multiplies and differentiates in the digestive tract of triatomine insects. These insects ingest an enormous amount of blood, with ingestion followed very rapidly by a strong diuresis, slow digestion and occasionally long periods of starvation. Resulting changes in the intestinal environment induce the development of dominant stages of T. cruzi – epimastigotes and metacyclic trypomastigotes – and can be correlated with the appearance of specific developmental stages – spheromastigotes and giant cells – which otherwise are only rarely seen. Here, Astrid Kollien and Günter Schaub outline recent research on these developmental steps of T. cruzi in the vector, and the effects of different compounds acting against the parasite in the vector.