大鼠两期双相发热时血清素中心池和甩尾潜伏期。

S V Koulchitsky, G K Tropnikova, G P Mironova, Y A Pesotskaya, A N German, V A Kulchitsky
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引用次数: 0

摘要

在雄性Wistar大鼠的实验中,通过预先植入颈静脉的硅导管,静脉注射大肠杆菌脂多糖(10 μ g/kg),诱导急性期反应。用热电偶测量结肠温度和皮肤温度。基于尾弹潜伏期(TFL)对有害热刺激的反应来评估伤害感觉的变化。在这项工作中,我们观察了TFL的双相发热的发展和阶段性变化,即急性期反应的第一阶段是痛觉过敏,第二阶段是痛觉减退。血清素的分解代谢在急性期反应初期中脑、纹状体和延髓前内侧的增加最为显著(平均分别增加20-25%、35-40%和95-100%)。在急性期反应的第二阶段,尽管纹状体、中脑和小脑的血清素含量显著增加,但这些中枢神经系统部分的血清素分解代谢没有显著变化,这与痛觉减退相吻合。因此,急性期反应开始后,TFL和结肠温度的相位变化伴随着脑不同部位血清素分解代谢的确定变化。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Central pool of serotonin and tail-flick latency during two phases of biphasic fever in rats.

In experiments on male Wistar rats, the acute phase reaction was induced by a bolus intravenous injection of Escherichia coli lipopolysaccharide (10 microg/kg) through a silicon catheter pre-implanted into the jugular vein. The colonic and skin temperature was measured with thermocouples. Changes in nociception were assessed based on tail flick latency (TFL) in response to a noxious heat stimulus. In this work, we observed the development of biphasic fever and phasic changes in TFL, namely, hyperalgesia in the first period of the acute phase reaction and hypoalgesia in its second phase. The catabolism of serotonin increased most considerably in the initial period of the acute phase reaction in the midbrain, striatum, and rostrodorsomedial medulla (on average, by 20-25%, 35-40%, and 95-100%, respectively). In the second phase of the acute phase reaction, despite a significant increase in the serotonin content in the striatum, midbrain, and cerebellum, there were no significant changes in serotonin catabolism in these parts of the CNS, which coincided with hypoalgesia. Thus, the phasic changes in TFL and colonic temperature after initiation of the acute phase reaction were accompanied by determinate changes in the catabolism of serotonin in different brain parts.

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