作为生命模拟系统的反胶束。

G G Chang, T M Huang, H C Hung
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引用次数: 0

摘要

在这篇综述中,我们试图证明反胶束是一种简单的人工系统,它模仿了许多生命系统,从细胞分裂到酶催化机制的产生。对于像胎盘碱性磷酸酶这样的膜性酶,在反胶束中观察到的动力学性质可能代表生理条件下的动力学性质。由带正电荷的表面活性剂组成的反胶束系统模拟了一种解毒酶谷胱甘肽转移酶。我们提出了一种新的油湖岛型谷胱甘肽转移酶的反胶束模型,该模型可以解释该酶的几乎所有催化性质。反胶束为研究其他解毒酶的反应机理提供了良好的模型体系。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Reverse micelles as life-mimicking systems.

In this review, we attempt to demonstrate that reverse micelles are simple artificial systems that mimic many life systems from cell division to the creation of an enzyme catalytic mechanism. For a membranous enzyme like placental alkaline phosphatase, the kinetic properties observed in reverse micelles might represent those found under physiological conditions. The reverse micellar system, consisting of a positively charged surfactant, mimics a detoxification enzyme glutathione transferase. We propose a novel island-in-oil-lake reverse micellar model for the glutathione transferase that can account for almost all the catalytic properties of this enzyme. Reverse micelles may provide an excellent model system in investigating the reaction mechanism of other detoxification enzymes.

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