{"title":"e -钙粘蛋白，雌激素和癌症:有联系吗?","authors":"O W Blaschuk, S B Munro, R Farookhi","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>E-cadherin is a calcium-dependent, epithelial cell adhesion molecule. It has recently been implicated as a tumor suppressor. This review article contains a description of the structure, function, and regulation of E-cadherin and other members comprising the cadherin family. In particular, we discuss studies concerning the ability of estrogens to modulate E-cadherin levels in vivo. Finally, we consider the hypothesis that estrogens may promote breast, uterine and ovarian cancer by down-regulating E-cadherin levels in these tissues.</p>","PeriodicalId":79379,"journal":{"name":"The Canadian journal of oncology","volume":"4 4","pages":"291-301"},"PeriodicalIF":0.0000,"publicationDate":"1994-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"E-cadherin, estrogens and cancer: is there a connection?\",\"authors\":\"O W Blaschuk, S B Munro, R Farookhi\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>E-cadherin is a calcium-dependent, epithelial cell adhesion molecule. It has recently been implicated as a tumor suppressor. This review article contains a description of the structure, function, and regulation of E-cadherin and other members comprising the cadherin family. In particular, we discuss studies concerning the ability of estrogens to modulate E-cadherin levels in vivo. Finally, we consider the hypothesis that estrogens may promote breast, uterine and ovarian cancer by down-regulating E-cadherin levels in these tissues.</p>\",\"PeriodicalId\":79379,\"journal\":{\"name\":\"The Canadian journal of oncology\",\"volume\":\"4 4\",\"pages\":\"291-301\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1994-11-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The Canadian journal of oncology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Canadian journal of oncology","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
E-cadherin, estrogens and cancer: is there a connection?
E-cadherin is a calcium-dependent, epithelial cell adhesion molecule. It has recently been implicated as a tumor suppressor. This review article contains a description of the structure, function, and regulation of E-cadherin and other members comprising the cadherin family. In particular, we discuss studies concerning the ability of estrogens to modulate E-cadherin levels in vivo. Finally, we consider the hypothesis that estrogens may promote breast, uterine and ovarian cancer by down-regulating E-cadherin levels in these tissues.
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