Susanna Cotecchia , Olivier Rossier , Francesca Fanelli , Amedeo Leonardi , Pier G De Benedetti
{"title":"α1a和α1b肾上腺素能受体亚型:受体活化和药物作用的分子机制","authors":"Susanna Cotecchia , Olivier Rossier , Francesca Fanelli , Amedeo Leonardi , Pier G De Benedetti","doi":"10.1016/S0031-6865(99)00031-X","DOIUrl":null,"url":null,"abstract":"<div><p>In this chapter we summarize some aspects of the structure-functional relationship of the α1a and α1b-adrenergic receptor subtypes related to the receptor activation process as well as the effect of different alpha-blockers on the constitutive activity of the receptor. Molecular modeling of the α1a and α1b-adrenergic receptor subtypes and computational simulation of receptor dynamics were useful to interpret the experimental findings derived from site directed mutagenesis studies.</p></div>","PeriodicalId":19830,"journal":{"name":"Pharmaceutica acta Helvetiae","volume":"74 2","pages":"Pages 173-179"},"PeriodicalIF":0.0000,"publicationDate":"2000-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0031-6865(99)00031-X","citationCount":"14","resultStr":"{\"title\":\"The α1a and α1b-adrenergic receptor subtypes: molecular mechanisms of receptor activation and of drug action\",\"authors\":\"Susanna Cotecchia , Olivier Rossier , Francesca Fanelli , Amedeo Leonardi , Pier G De Benedetti\",\"doi\":\"10.1016/S0031-6865(99)00031-X\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>In this chapter we summarize some aspects of the structure-functional relationship of the α1a and α1b-adrenergic receptor subtypes related to the receptor activation process as well as the effect of different alpha-blockers on the constitutive activity of the receptor. Molecular modeling of the α1a and α1b-adrenergic receptor subtypes and computational simulation of receptor dynamics were useful to interpret the experimental findings derived from site directed mutagenesis studies.</p></div>\",\"PeriodicalId\":19830,\"journal\":{\"name\":\"Pharmaceutica acta Helvetiae\",\"volume\":\"74 2\",\"pages\":\"Pages 173-179\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2000-03-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/S0031-6865(99)00031-X\",\"citationCount\":\"14\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Pharmaceutica acta Helvetiae\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S003168659900031X\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pharmaceutica acta Helvetiae","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S003168659900031X","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
The α1a and α1b-adrenergic receptor subtypes: molecular mechanisms of receptor activation and of drug action
In this chapter we summarize some aspects of the structure-functional relationship of the α1a and α1b-adrenergic receptor subtypes related to the receptor activation process as well as the effect of different alpha-blockers on the constitutive activity of the receptor. Molecular modeling of the α1a and α1b-adrenergic receptor subtypes and computational simulation of receptor dynamics were useful to interpret the experimental findings derived from site directed mutagenesis studies.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
