改良Lundh试验评估胰酶分泌能力。

L Czakó, F Hajnal, J Németh, J Lonovics
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引用次数: 8

摘要

背景:伦德试验是估计腺体酶分泌能力的常用手段。然而,在此过程中,大部分试验饲料连同胃、十二指肠、胰腺分泌物和胆汁一起从十二指肠取出。本研究是为了比较Lundh手术诱导的胰酶分泌与通过回输吸入的十二指肠液刺激正常消化过程所产生的胰酶分泌。方法:9例无胰腺疾病的男性,平均年龄46.7岁,42 ~ 55岁。胰分泌量通过多腔管吸入十二指肠液测定。在基础期后,将Lundh试验餐放入胃中,并完全吸出十二指肠液。在另一天,重复该程序,但将抽吸的十二指肠液重新注入上部空肠。结果:在试验前30分钟,两个试验日的酶输出量相同。Lundh试验在30-60 min期间脂肪酶排泄量显著低于空肠回输试验,在75-90 min期间淀粉酶排泄量显著低于空肠回输试验。CCK水平在20和40 min显著高于基础水平,但在传统Lundh试验中,CCK水平的升高明显低于基础水平。在Lundh和回输试验期间,胃泌素释放均无显著差异。结论:在传统的Lundh试验中,腺体胰蛋白酶分泌能力得到了适当的测量,但脂肪酶和淀粉酶分泌能力和CCK释放量与回输试验相比没有得到充分的反映。低CCK释放与脂肪酶淀粉酶分泌之间存在关联。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Assessment of pancreatic enzyme secretory capacity by a modified Lundh test.

Background: The Lundh test is a usual means of estimating the enzyme secretory capacity of the gland. During this procedure, however, a major proportion of the test meal is removed from the duodenum together with the gastric, duodenal, and pancreatic secretions and the bile. This study was undertaken to compare the pancreatic enzyme secretion induced by the Lundh procedure with that resulting from stimulation of the normal digestive process, by reinfusion of the aspirated duodenal juice.

Methods: Nine men (mean age: 46.7, range 42-55 yr) free from pancreatic disease were studied. Pancreatic secretion was measured via a multiple lumen tube by aspiration of the duodenal juice. After a basal period the Lundh test meal was placed in the stomach and the duodenal juice was completely aspirated. On a separate day, the procedure was repeated, but the aspirated duodenal juice was reinfused into the upper jejunum.

Results: In the first 30 min of the test period, the enzyme outputs were the same on both test days. In the 30-60-min period, the lipase output, and in the 75-90-min period, the amylase output was significantly lower during the Lundh test compared with the jejunal reinfusion test. The CCK levels were significantly above the basal level at 20 and 40 min, but the increase was significantly lower during the traditional Lundh test. No significant difference in gastrin release was observed during either the Lundh or the reinfusion test.

Conclusions: In the traditional Lundh test, the trypsin secretory capacities of the gland are measured appropriately, but the lipase and amylase secretory capacity and the CCK release are not fully represented compared with the reinfusion test. An association between the lower CCK release and lipase amylase secretion is suggested.

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