选择性内毛细胞丢失导致的中枢听觉系统听觉剥夺:听神经病变动物模型。

Scandinavian audiology. Supplementum Pub Date : 1999-01-01
R J Salvi, J Wang, D Ding, N Stecker, S Arnold
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引用次数: 0

摘要

听神经病变常表现为阈值正常、耳声发射存在、言语辨别能力差、声反射缺失、听脑干反应波形缺失或异常,但皮层晚期电位正常。本文描述了一种具有多种听神经病变特征的动物模型。卡铂是一种抗肿瘤药物,可以选择性地破坏内毛细胞(IHCs)和I型听神经纤维,通过给予卡铂可以剥夺龙猫中枢听觉系统的很大一部分神经输入。选择性IHC损失对畸变产物耳声发射或耳蜗传声器电位没有影响,表明外毛细胞功能正常。然而,选择性IHC损失导致复合动作电位的幅度与IHC损失的程度成比例地降低。然而,随着IHC轻度至中度损失,CAP阈值几乎没有增加。在轻度至中度IHC损失的耳朵中,听觉反应性听神经纤维具有正常的阈值和窄调谐曲线。虽然中央听觉通路被剥夺了大部分的感觉输入,但听觉皮层的局部场电位振幅正常或增强,而来自下丘的场电位振幅略有降低。结果与听神经病变患者的结果有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Auditory deprivation of the central auditory system resulting from selective inner hair cell loss: animal model of auditory neuropathy.

Auditory neuropathy is often characterized by normal thresholds, present otoacoustic emissions, poor speech discrimination, absent acoustic reflexes, absent or abnormal auditory brainstem response waveform, but normal late cortical potential. This paper describes an animal model that has many characteristics of auditory neuropathy. Chinchillas can be deprived of a significant portion of the neural inputs to the central auditory system by administering carboplatin, an antineoplastic agent that selectively destroys inner hair cells (IHCs) and type I auditory nerve fibers. Selective IHC loss has no effect on distortion product otoacoustic emissions or the cochlear microphonic potential, implying normal outer hair cell function. However, selective IHC loss causes the amplitude of the compound action potential to decrease in proportion to the degree of IHC loss. However, the threshold of the CAP shows little increase with mild to moderate IHC loss. Acoustically responsive auditory nerve fibers in ears with mild to moderate IHC loss have normal thresholds and tuning curves with narrowly tuned tips. Although the central auditory pathway is deprived of much of its sensory inputs, the amplitude of the local field potential in the auditory cortex was normal or enhanced, while those from the inferior colliculus were slightly reduced. The results are related to those of a patient with auditory neuropathy.

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