新型10-取代1,8-二羟基-9(10H)-蒽酮衍生物的质谱表征。

H S Huang, P Y Lin
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引用次数: 0

摘要

蒽醌及其衍生物含有多种简单或功能化的脂肪族和芳香族取代基,是银屑病的研究热点。在此基础上,合成了10-芳基硫基-1,8-二羟基-9(10H)-蒽酮,并用质谱法对其进行了分析。一般来说,所讨论的分子在电子冲击下分裂成m/z 225处的离子(C-S键断裂和炭素成分的电荷保留),并在m/z 226处分裂成未知结构的离子,这需要h从s键取代基R迁移到炭素部分。由于质谱法为我们提供了优雅的、无与伦比的方法来追踪分析中物质的数量,特别是在生理活性化合物的情况下,我们决定使用质谱法对10-芳基硫代蒽醛进行明确的鉴定和纯度测定。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Characterization of novel 10-substituted 1,8-dihydroxy-9(10H)-anthracenone derivatives by mass spectrometry.

Anthralin and its derivatives containing a variety of simple or functionalized aliphatic and aromatic substituents are of special interest in research on psoriasis. In this connection, 10-arylthio-1,8-dihydroxy-9(10H)-anthracenones were synthesized and examined by means of mass spectrometry. In general, the molecules in question fragmented upon electron impact into ions at m/z 225 (C-S bond cleavage and charge retention at the anthralin component) and into ions of unknown structure at m/z 226, requiring H-migration from the S-bound substituent R into the anthralin moiety. Since mass spectrometry methods furnished us elegant, matchless means of tracing the amounts of material in the analysis, especially in the case of physiologically active compounds, we decided to use mass spectrometry procedures for unequivocal identification and purity determination of 10-arylthio-anthralins.

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